-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.

Sodium nitrite is widely used as a color fixative and preservative in meat and fish. Impairment of hepatic function and disturbances in lipid metabolism are well recognized adverse effects of sodium nitrite. The aim of this study is to investigate the role of bis [4-(4'-hydroxy-3'-methox...

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Main Authors:	Mohammed A. Al-Diwan Shaker A. S. N. AL, Hiathem J. Kadhum, Jadaan
Format:	Article
Language:	English
Published:	College of Veterinary Medicine, University of Basrah, Iraq 2015-06-01
Series:	Basrah Journal of Veterinary Research
Subjects:	keywords liver enzymes sodium nitrite
Online Access:	https://bjvr.uobasrah.edu.iq/article_99660_464547dfbe142703fe15fd4cdf794484.pdf
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author	Mohammed A. Al-Diwan Shaker A. S. N. AL Hiathem J. Kadhum Jadaan
author_facet	Mohammed A. Al-Diwan Shaker A. S. N. AL Hiathem J. Kadhum Jadaan
author_sort	Mohammed A. Al-Diwan Shaker A. S. N. AL
collection	DOAJ
description	Sodium nitrite is widely used as a color fixative and preservative in meat and fish. Impairment of hepatic function and disturbances in lipid metabolism are well recognized adverse effects of sodium nitrite. The aim of this study is to investigate the role of bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride, a novel compound, in preventing the hepatic damage and disturbances of lipid metabolism induced by sodium nitrite toxicity in male albino rats. The estimated LD50 of [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride in adult male albino rats is 218.7 mg/kg body weight. Rats given sodium nitrite (0.2%) in the drinking water showed a significant increase in serum ALT, AST, ALP, Total cholesterol, TG. LDL and VLDL while HDL significantly reduced. These changes are reversed by administration of bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride in a dose of 11mg/kg body weight corresponding to 1/20 LD50. It is concluded that bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride is effective in preventing hepatic damage and dislipidemia in sodium nitrite intoxicated male rats.
format	Article
id	doaj-art-da70b44783c14347bd16e4ead0bc299f
institution	OA Journals
issn	1813-8497 2410-8456
language	English
publishDate	2015-06-01
publisher	College of Veterinary Medicine, University of Basrah, Iraq
record_format	Article
series	Basrah Journal of Veterinary Research
spelling	doaj-art-da70b44783c14347bd16e4ead0bc299f2025-08-20T02:31:33ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562015-06-01141122510.33762/bvetr.2015.9966099660-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.Mohammed A. Al-Diwan Shaker A. S. N. ALHiathem J. KadhumJadaanSodium nitrite is widely used as a color fixative and preservative in meat and fish. Impairment of hepatic function and disturbances in lipid metabolism are well recognized adverse effects of sodium nitrite. The aim of this study is to investigate the role of bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride, a novel compound, in preventing the hepatic damage and disturbances of lipid metabolism induced by sodium nitrite toxicity in male albino rats. The estimated LD50 of [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride in adult male albino rats is 218.7 mg/kg body weight. Rats given sodium nitrite (0.2%) in the drinking water showed a significant increase in serum ALT, AST, ALP, Total cholesterol, TG. LDL and VLDL while HDL significantly reduced. These changes are reversed by administration of bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride in a dose of 11mg/kg body weight corresponding to 1/20 LD50. It is concluded that bis [4-(4'-hydroxy-3'-methoxybezylidineaminophenyl)]telluride is effective in preventing hepatic damage and dislipidemia in sodium nitrite intoxicated male rats.https://bjvr.uobasrah.edu.iq/article_99660_464547dfbe142703fe15fd4cdf794484.pdfkeywordsliver enzymessodium nitrite
spellingShingle	Mohammed A. Al-Diwan Shaker A. S. N. AL Hiathem J. Kadhum Jadaan -HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS. Basrah Journal of Veterinary Research keywords liver enzymes sodium nitrite
title	-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.
title_full	-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.
title_fullStr	-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.
title_full_unstemmed	-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.
title_short	-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.
title_sort	hepatoprotective and hypolipidemic effects of bis 4 4 hydroxy 3 methoxybezylidineaminophenyl telluride r2te against sodium nitrite intoxication in male albino rats
topic	keywords liver enzymes sodium nitrite
url	https://bjvr.uobasrah.edu.iq/article_99660_464547dfbe142703fe15fd4cdf794484.pdf
work_keys_str_mv	AT mohammedaaldiwanshakerasnal hepatoprotectiveandhypolipidemiceffectsofbis44hydroxy3methoxybezylidineaminophenyltellurider2teagainstsodiumnitriteintoxicationinmalealbinorats AT hiathemjkadhum hepatoprotectiveandhypolipidemiceffectsofbis44hydroxy3methoxybezylidineaminophenyltellurider2teagainstsodiumnitriteintoxicationinmalealbinorats AT jadaan hepatoprotectiveandhypolipidemiceffectsofbis44hydroxy3methoxybezylidineaminophenyltellurider2teagainstsodiumnitriteintoxicationinmalealbinorats

-HEPATOPROTECTIVE AND HYPOLIPIDEMIC EFFECTS OF BIS [4-(4'-HYDROXY-3'-METHOXYBEZYLIDINEAMINOPHENYL) ]TELLURIDE (R2TE) AGAINST SODIUM NITRITE INTOXICATION IN MALE ALBINO RATS.

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