Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature
Hypereosinophilia, either clonal or reactive, has been described in association with multiple hematological malignancies. We describe a case of a patient presenting with hypereosinophilia that evolved into T-cell lymphoblastic lymphoma. Complete remission was achieved with chemotherapy; however, hyp...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/652745 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166476439289856 |
|---|---|
| author | Filipa Moita Isabel Bogalho Helena Alaiz Joana Parreira Maria Jesus Frade Albertina Nunes Maria Gomes da Silva |
| author_facet | Filipa Moita Isabel Bogalho Helena Alaiz Joana Parreira Maria Jesus Frade Albertina Nunes Maria Gomes da Silva |
| author_sort | Filipa Moita |
| collection | DOAJ |
| description | Hypereosinophilia, either clonal or reactive, has been described in association with multiple hematological malignancies. We describe a case of a patient presenting with hypereosinophilia that evolved into T-cell lymphoblastic lymphoma. Complete remission was achieved with chemotherapy; however, hypereosinophilia recurred 5 months later in association with myeloblastic bone marrow infiltration and without evidence of lymphoblastic lymphoma relapse. Cytogenetic analysis of the bone marrow showed a complex translocation involving chromosomes 7, 12, and 16. A rearrangement of ETV6 gene (12p13) was demonstrated by FISH studies, thus confirming the clonality of this population. The association of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia has been described in disorders with FGFR1 rearrangements. We hypothesize that other clonal eosinophilic disorders lacking this rearrangement could behave in a similar fashion through different pathogenic mechanisms. |
| format | Article |
| id | doaj-art-da6f4c4b1bd048a7941849d6a0e4cfb1 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-da6f4c4b1bd048a7941849d6a0e4cfb12025-08-20T02:21:25ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/652745652745Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the LiteratureFilipa Moita0Isabel Bogalho1Helena Alaiz2Joana Parreira3Maria Jesus Frade4Albertina Nunes5Maria Gomes da Silva6Hematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Rua Professor Lima Basto, 1099-213 Lisbon, PortugalHematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Rua Professor Lima Basto, 1099-213 Lisbon, PortugalHematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Rua Professor Lima Basto, 1099-213 Lisbon, PortugalHematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Rua Professor Lima Basto, 1099-213 Lisbon, PortugalHematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Rua Professor Lima Basto, 1099-213 Lisbon, PortugalHematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Rua Professor Lima Basto, 1099-213 Lisbon, PortugalHematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Rua Professor Lima Basto, 1099-213 Lisbon, PortugalHypereosinophilia, either clonal or reactive, has been described in association with multiple hematological malignancies. We describe a case of a patient presenting with hypereosinophilia that evolved into T-cell lymphoblastic lymphoma. Complete remission was achieved with chemotherapy; however, hypereosinophilia recurred 5 months later in association with myeloblastic bone marrow infiltration and without evidence of lymphoblastic lymphoma relapse. Cytogenetic analysis of the bone marrow showed a complex translocation involving chromosomes 7, 12, and 16. A rearrangement of ETV6 gene (12p13) was demonstrated by FISH studies, thus confirming the clonality of this population. The association of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia has been described in disorders with FGFR1 rearrangements. We hypothesize that other clonal eosinophilic disorders lacking this rearrangement could behave in a similar fashion through different pathogenic mechanisms.http://dx.doi.org/10.1155/2013/652745 |
| spellingShingle | Filipa Moita Isabel Bogalho Helena Alaiz Joana Parreira Maria Jesus Frade Albertina Nunes Maria Gomes da Silva Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature Case Reports in Hematology |
| title | Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature |
| title_full | Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature |
| title_fullStr | Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature |
| title_full_unstemmed | Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature |
| title_short | Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature |
| title_sort | clonal hypereosinophilia with etv6 rearrangement evolving to t cell lymphoblastic lymphoma a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2013/652745 |
| work_keys_str_mv | AT filipamoita clonalhypereosinophiliawithetv6rearrangementevolvingtotcelllymphoblasticlymphomaacasereportandreviewoftheliterature AT isabelbogalho clonalhypereosinophiliawithetv6rearrangementevolvingtotcelllymphoblasticlymphomaacasereportandreviewoftheliterature AT helenaalaiz clonalhypereosinophiliawithetv6rearrangementevolvingtotcelllymphoblasticlymphomaacasereportandreviewoftheliterature AT joanaparreira clonalhypereosinophiliawithetv6rearrangementevolvingtotcelllymphoblasticlymphomaacasereportandreviewoftheliterature AT mariajesusfrade clonalhypereosinophiliawithetv6rearrangementevolvingtotcelllymphoblasticlymphomaacasereportandreviewoftheliterature AT albertinanunes clonalhypereosinophiliawithetv6rearrangementevolvingtotcelllymphoblasticlymphomaacasereportandreviewoftheliterature AT mariagomesdasilva clonalhypereosinophiliawithetv6rearrangementevolvingtotcelllymphoblasticlymphomaacasereportandreviewoftheliterature |