Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq.
Background and objective: Programmed death ligand-1 protein expression has been linked to the severity of Urothelial cancer. The objectives of this study were to evaluate the expression of programmed death-ligand 1 and determine the association with tumour grade, stage, type (Papillary and non papi...
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Kurdistan Higher Council Of Medical Specialties
2024-06-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/416 |
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| author | Zuzan Shawkat Mustafa Gina James Keorges Alaa Hani Raziq |
| author_facet | Zuzan Shawkat Mustafa Gina James Keorges Alaa Hani Raziq |
| author_sort | Zuzan Shawkat Mustafa |
| collection | DOAJ |
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Background and objective: Programmed death ligand-1 protein expression has been linked to the severity of Urothelial cancer. The objectives of this study were to evaluate the expression of programmed death-ligand 1 and determine the association with tumour grade, stage, type (Papillary and non papillary), muscle invasion, age, and gender.
Methods: This retrospective study was carried out from 2015 to 2022 on fifty-eight blocks belonging to patients with urothelial carcinoma, which were obtained from Duhok central lab and private laboratory. From each block, two sections were made; one of which was stained with Hematoxylin and Eosin for histological re-assessment and the other one for immunostaining for programmed death-ligand-1, which was calculated in tumour cells and inflammatory cells regardless of staining intensity and then the combined positive score was determined and considered positive when is more than 10.
Result: This study included 58 cases of Urothelial carcinoma, Females represent 8 (13.79%) cases and males 50 (86.21%) cases, with a female-to-male ratio of 1/6.25. No statistically significant association existed between the histological subtypes and gender. Combined positive score was positive in (32.76%) of cases and negative (67.24%) cases. The association was significant with the stage of the tumor (p=0.03), muscle invasion (p=0.02) and highly significant with grade (p<0.001).
Conclusion: patients with urothelial carcinoma who have higher tumour grade, advanced stage and those who with muscle invasion can benefit from immune check point inhibitors.
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| format | Article |
| id | doaj-art-da636099eb5349bcbb0d2fe43e4bb1a1 |
| institution | OA Journals |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-da636099eb5349bcbb0d2fe43e4bb1a12025-08-20T02:17:33ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802024-06-019210.56056/amj.2024.257Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq.Zuzan Shawkat Mustafa 0Gina James Keorges1Alaa Hani Raziq2Department of Histopathology, Central Lab, Duhok. FICMS. Lecturer - Department of Pathology, College of Medicine, University of DuhokFICMS. Professor - Department of Pathology, College of Medicine, University of Duhok Background and objective: Programmed death ligand-1 protein expression has been linked to the severity of Urothelial cancer. The objectives of this study were to evaluate the expression of programmed death-ligand 1 and determine the association with tumour grade, stage, type (Papillary and non papillary), muscle invasion, age, and gender. Methods: This retrospective study was carried out from 2015 to 2022 on fifty-eight blocks belonging to patients with urothelial carcinoma, which were obtained from Duhok central lab and private laboratory. From each block, two sections were made; one of which was stained with Hematoxylin and Eosin for histological re-assessment and the other one for immunostaining for programmed death-ligand-1, which was calculated in tumour cells and inflammatory cells regardless of staining intensity and then the combined positive score was determined and considered positive when is more than 10. Result: This study included 58 cases of Urothelial carcinoma, Females represent 8 (13.79%) cases and males 50 (86.21%) cases, with a female-to-male ratio of 1/6.25. No statistically significant association existed between the histological subtypes and gender. Combined positive score was positive in (32.76%) of cases and negative (67.24%) cases. The association was significant with the stage of the tumor (p=0.03), muscle invasion (p=0.02) and highly significant with grade (p<0.001). Conclusion: patients with urothelial carcinoma who have higher tumour grade, advanced stage and those who with muscle invasion can benefit from immune check point inhibitors. https://amj.khcms.edu.krd/index.php/main/article/view/416Combined positive scorePDL-1Urothelial cancer |
| spellingShingle | Zuzan Shawkat Mustafa Gina James Keorges Alaa Hani Raziq Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq. Advanced Medical Journal Combined positive score PDL-1 Urothelial cancer |
| title | Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq. |
| title_full | Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq. |
| title_fullStr | Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq. |
| title_full_unstemmed | Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq. |
| title_short | Programmed Death Ligand 1 expression in Urothelial Carcinoma.A retrospective study in Duhok City-Iraq. |
| title_sort | programmed death ligand 1 expression in urothelial carcinoma a retrospective study in duhok city iraq |
| topic | Combined positive score PDL-1 Urothelial cancer |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/416 |
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