The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss
Recurrent pregnancy loss (RPL) is both mental and physical health problem affecting about 1–5% of women of childbearing age. The etiology of RPL is complex, involving chromosomal abnormalities, autoimmune diseases, metabolic disorders, and endometrial dysfunction. The causes of abortion are still un...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2023/9164374 |
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| _version_ | 1849470874490503168 |
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| author | Qinlan Li Shuting Chen Xinyi Dong Sen Fu Tianyu Zhang Weiwei Zheng Yonghong Tian Donghui Huang |
| author_facet | Qinlan Li Shuting Chen Xinyi Dong Sen Fu Tianyu Zhang Weiwei Zheng Yonghong Tian Donghui Huang |
| author_sort | Qinlan Li |
| collection | DOAJ |
| description | Recurrent pregnancy loss (RPL) is both mental and physical health problem affecting about 1–5% of women of childbearing age. The etiology of RPL is complex, involving chromosomal abnormalities, autoimmune diseases, metabolic disorders, and endometrial dysfunction. The causes of abortion are still unknown in more than 50% of these cases. With the development of science and technology, an increasing number of scholars focus on this field and find that genetic factors may play an essential role in unexplained RPL, such as embolism-related genes, immune factor-related genes, and chromosomal numeric, and structural variation. This review summarizes the genetic factors associated with RPL, including genetic mutations and genetic polymorphisms, chromosomal variants, and chromosomal polymorphisms. Many related genetic factors have been found to be demographically and geographically relevant, some of which can be used for risk prediction or screening for the etiology of RPL. However, it is difficult to predict and prevent RPL due to uncertain pathogenesis and highly variable clinical presentation. Therefore, the genetic factors of RPL still need plentiful research to obtain a more accurate understanding of its pathogenesis and to provide more detection means for the screening and prevention of RPL. |
| format | Article |
| id | doaj-art-da5ca825f3aa498ab295a44fca18cf59 |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-da5ca825f3aa498ab295a44fca18cf592025-08-20T03:25:00ZengWileyGenetics Research1469-50732023-01-01202310.1155/2023/9164374The Progress of Research on Genetic Factors of Recurrent Pregnancy LossQinlan Li0Shuting Chen1Xinyi Dong2Sen Fu3Tianyu Zhang4Weiwei Zheng5Yonghong Tian6Donghui Huang7Institute of Reproduction Health ResearchInstitute of Reproduction Health ResearchInstitute of Reproduction Health ResearchInstitute of Reproduction Health ResearchInstitute of Reproduction Health ResearchNHC Key Laboratory of Male Reproduction and Genetics (Family Planning Research Institute of Guangdong Province)Department of Reproductive EndocrinologyInstitute of Reproduction Health ResearchRecurrent pregnancy loss (RPL) is both mental and physical health problem affecting about 1–5% of women of childbearing age. The etiology of RPL is complex, involving chromosomal abnormalities, autoimmune diseases, metabolic disorders, and endometrial dysfunction. The causes of abortion are still unknown in more than 50% of these cases. With the development of science and technology, an increasing number of scholars focus on this field and find that genetic factors may play an essential role in unexplained RPL, such as embolism-related genes, immune factor-related genes, and chromosomal numeric, and structural variation. This review summarizes the genetic factors associated with RPL, including genetic mutations and genetic polymorphisms, chromosomal variants, and chromosomal polymorphisms. Many related genetic factors have been found to be demographically and geographically relevant, some of which can be used for risk prediction or screening for the etiology of RPL. However, it is difficult to predict and prevent RPL due to uncertain pathogenesis and highly variable clinical presentation. Therefore, the genetic factors of RPL still need plentiful research to obtain a more accurate understanding of its pathogenesis and to provide more detection means for the screening and prevention of RPL.http://dx.doi.org/10.1155/2023/9164374 |
| spellingShingle | Qinlan Li Shuting Chen Xinyi Dong Sen Fu Tianyu Zhang Weiwei Zheng Yonghong Tian Donghui Huang The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss Genetics Research |
| title | The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss |
| title_full | The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss |
| title_fullStr | The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss |
| title_full_unstemmed | The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss |
| title_short | The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss |
| title_sort | progress of research on genetic factors of recurrent pregnancy loss |
| url | http://dx.doi.org/10.1155/2023/9164374 |
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