Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis
Abstract Background Follitropin δ may be an alternative to conventional follitropin α/β for controlled ovarian stimulation (COS) within assisted reproductive treatment (ART), but its efficacy and safety remain unknown. We performed a random‐effects meta‐analysis to compare the efficacy and safety of...
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| Format: | Article |
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Wiley
2024-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12573 |
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| author | Shinnosuke Komiya Jun Watanabe Takero Terayama Kyosuke Kamijo Hidetaka Okada |
| author_facet | Shinnosuke Komiya Jun Watanabe Takero Terayama Kyosuke Kamijo Hidetaka Okada |
| author_sort | Shinnosuke Komiya |
| collection | DOAJ |
| description | Abstract Background Follitropin δ may be an alternative to conventional follitropin α/β for controlled ovarian stimulation (COS) within assisted reproductive treatment (ART), but its efficacy and safety remain unknown. We performed a random‐effects meta‐analysis to compare the efficacy and safety of follitropin δ and follitropin α/β. Methods We searched randomized controlled trials comparing follitropin δ and follitropin α/β using MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, and WHO‐ITCRP on December 14, 2022. The primary outcomes were the live birth rate and the incidence of moderate or severe ovarian hyperstimulation syndrome (OHSS). The certainty of the evidence was assessed using the grading of recommendations assessment, development, and evaluation approach. The protocol was registered on the Open Science Framework. Results Three studies involving 2682 participants were included in our meta‐analysis. The results indicated that follitropin δ may result in little to no difference in live birth rates (risk ratio [RR], 1.12; 95% confidence interval [CI], 0.91–1.38; low certainty) and the incidence of moderate or severe OHSS (RR, 0.78; 95% CI, 0.48–1.26; low certainty) compared with follitropin α/β. Conclusion Follitropin δ may result in little to no difference in COS compared with follitropin α/β, especially in terms of live births and safety. |
| format | Article |
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| institution | DOAJ |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
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| series | Reproductive Medicine and Biology |
| spelling | doaj-art-da5bd65a19a54f5cba194122fab5a79b2025-08-20T02:52:37ZengWileyReproductive Medicine and Biology1445-57811447-05782024-01-01231n/an/a10.1002/rmb2.12573Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysisShinnosuke Komiya0Jun Watanabe1Takero Terayama2Kyosuke Kamijo3Hidetaka Okada4HORAC Grand Front Osaka Clinic Osaka JapanSystematic Review Workshop Peer Support Group (SRWS‐PSG) Osaka JapanSystematic Review Workshop Peer Support Group (SRWS‐PSG) Osaka JapanSystematic Review Workshop Peer Support Group (SRWS‐PSG) Osaka JapanDepartment of Obstetrics and Gynecology Kansai Medical University Graduate School of Medicine Hirakata, Osaka JapanAbstract Background Follitropin δ may be an alternative to conventional follitropin α/β for controlled ovarian stimulation (COS) within assisted reproductive treatment (ART), but its efficacy and safety remain unknown. We performed a random‐effects meta‐analysis to compare the efficacy and safety of follitropin δ and follitropin α/β. Methods We searched randomized controlled trials comparing follitropin δ and follitropin α/β using MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, and WHO‐ITCRP on December 14, 2022. The primary outcomes were the live birth rate and the incidence of moderate or severe ovarian hyperstimulation syndrome (OHSS). The certainty of the evidence was assessed using the grading of recommendations assessment, development, and evaluation approach. The protocol was registered on the Open Science Framework. Results Three studies involving 2682 participants were included in our meta‐analysis. The results indicated that follitropin δ may result in little to no difference in live birth rates (risk ratio [RR], 1.12; 95% confidence interval [CI], 0.91–1.38; low certainty) and the incidence of moderate or severe OHSS (RR, 0.78; 95% CI, 0.48–1.26; low certainty) compared with follitropin α/β. Conclusion Follitropin δ may result in little to no difference in COS compared with follitropin α/β, especially in terms of live births and safety.https://doi.org/10.1002/rmb2.12573assisted reproductive techniquesfemale infertilityfertilization in vitrofollicle‐stimulating hormoneovarian hyperstimulation syndrome |
| spellingShingle | Shinnosuke Komiya Jun Watanabe Takero Terayama Kyosuke Kamijo Hidetaka Okada Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis Reproductive Medicine and Biology assisted reproductive techniques female infertility fertilization in vitro follicle‐stimulating hormone ovarian hyperstimulation syndrome |
| title | Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis |
| title_full | Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis |
| title_fullStr | Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis |
| title_full_unstemmed | Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis |
| title_short | Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis |
| title_sort | efficacy and safety of follitropin delta versus follitropin alpha beta in infertility treatment a systematic review and meta analysis |
| topic | assisted reproductive techniques female infertility fertilization in vitro follicle‐stimulating hormone ovarian hyperstimulation syndrome |
| url | https://doi.org/10.1002/rmb2.12573 |
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