Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction

Background: Immune dysregulation triggered by environmental events (including microbes) have been implicated in the etiopathogenesis of systemic sclerosis (SSc). Helicobacter pylori (H. pylori) a pathogen well known to cause gastric ulcers and has been associated with several autoimmune diseases. Ho...

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Main Authors: Chilukuri Balaji, Mahendran Bhuvanesh, Chinnadurai Saranya, Ramamoorthy Ramesh, Mayilsamy Saravanan, Sankaralingam Rajeswari
Format: Article
Language:English
Published: SAGE Publishing 2017-01-01
Series:Indian Journal of Rheumatology
Subjects:
Online Access:http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=4;spage=204;epage=208;aulast=Balaji
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author Chilukuri Balaji
Mahendran Bhuvanesh
Chinnadurai Saranya
Ramamoorthy Ramesh
Mayilsamy Saravanan
Sankaralingam Rajeswari
author_facet Chilukuri Balaji
Mahendran Bhuvanesh
Chinnadurai Saranya
Ramamoorthy Ramesh
Mayilsamy Saravanan
Sankaralingam Rajeswari
author_sort Chilukuri Balaji
collection DOAJ
description Background: Immune dysregulation triggered by environmental events (including microbes) have been implicated in the etiopathogenesis of systemic sclerosis (SSc). Helicobacter pylori (H. pylori) a pathogen well known to cause gastric ulcers and has been associated with several autoimmune diseases. However, the role of H. pylori in SSc has not been widely reported. The objective of the study was to estimate the prevalence of H. pylori infection in SSc patients and analyze its clinical associations. Methods: This study comprised 55 patients who satisfied ACR/EULAR 2013 classification criteria for SSc and 25 age and sex-matched healthy controls. Demographic, clinical, laboratory, and immunological parameters were recorded. Upper gastrointestinal (GI) endoscopy was done. Anti-H. pylori IgG levels (RU/ml) were estimated by ELISA and results analyzed by SPSS. Results: Baseline characteristics were comparable in both groups. Prevalence of H. pylori infection was high in SSc patients in comparison to controls (61.8% vs. 24%). Anti-H. pylori IgG levels were high in SSc patients in comparison to controls (mean 65 RU/ml vs. 25.3RU/ml; P = 0.003). SSc patients with symptomatic GI involvement had higher anti-H. pylori IgG levels than asymptomatic patients (mean 118.3 RU/ml vs. 20.7 RU/ml; P < 0.001). Anti-H. pylori IgG levels were not significantly different between diffuse cutaneous SSc and limited cutaneous SSc (mean 72.9 RU/ml vs. 54.1RU/ml; P = 0.289). Anti-H. pylori IgG antibody levels showed no correlation with disease duration, erythrocyte sedimentation rate, C-reactive protein, interstitial lung disease, and modified Rodnan Skin Score. Conclusion: SSc patients have high seropositivity for anti-H. pylori IgG antibodies. High anti-H. pylori IgG antibody titers are associated with symptomatic upper GI dysfunction.
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spelling doaj-art-da56ada724b541ad9c0f73c060b6798d2025-02-03T11:04:37ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012017-01-0112420420810.4103/injr.injr_62_17Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunctionChilukuri BalajiMahendran BhuvaneshChinnadurai SaranyaRamamoorthy RameshMayilsamy SaravananSankaralingam RajeswariBackground: Immune dysregulation triggered by environmental events (including microbes) have been implicated in the etiopathogenesis of systemic sclerosis (SSc). Helicobacter pylori (H. pylori) a pathogen well known to cause gastric ulcers and has been associated with several autoimmune diseases. However, the role of H. pylori in SSc has not been widely reported. The objective of the study was to estimate the prevalence of H. pylori infection in SSc patients and analyze its clinical associations. Methods: This study comprised 55 patients who satisfied ACR/EULAR 2013 classification criteria for SSc and 25 age and sex-matched healthy controls. Demographic, clinical, laboratory, and immunological parameters were recorded. Upper gastrointestinal (GI) endoscopy was done. Anti-H. pylori IgG levels (RU/ml) were estimated by ELISA and results analyzed by SPSS. Results: Baseline characteristics were comparable in both groups. Prevalence of H. pylori infection was high in SSc patients in comparison to controls (61.8% vs. 24%). Anti-H. pylori IgG levels were high in SSc patients in comparison to controls (mean 65 RU/ml vs. 25.3RU/ml; P = 0.003). SSc patients with symptomatic GI involvement had higher anti-H. pylori IgG levels than asymptomatic patients (mean 118.3 RU/ml vs. 20.7 RU/ml; P < 0.001). Anti-H. pylori IgG levels were not significantly different between diffuse cutaneous SSc and limited cutaneous SSc (mean 72.9 RU/ml vs. 54.1RU/ml; P = 0.289). Anti-H. pylori IgG antibody levels showed no correlation with disease duration, erythrocyte sedimentation rate, C-reactive protein, interstitial lung disease, and modified Rodnan Skin Score. Conclusion: SSc patients have high seropositivity for anti-H. pylori IgG antibodies. High anti-H. pylori IgG antibody titers are associated with symptomatic upper GI dysfunction.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=4;spage=204;epage=208;aulast=BalajiAutoimmuneesophagitisinfectionspathogenesisscleroderma
spellingShingle Chilukuri Balaji
Mahendran Bhuvanesh
Chinnadurai Saranya
Ramamoorthy Ramesh
Mayilsamy Saravanan
Sankaralingam Rajeswari
Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction
Indian Journal of Rheumatology
Autoimmune
esophagitis
infections
pathogenesis
scleroderma
title Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction
title_full Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction
title_fullStr Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction
title_full_unstemmed Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction
title_short Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction
title_sort helicobacter pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction
topic Autoimmune
esophagitis
infections
pathogenesis
scleroderma
url http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=4;spage=204;epage=208;aulast=Balaji
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AT mahendranbhuvanesh helicobacterpyloriinfectioninsystemicsclerosisanditsassociationwithuppergastrointestinaldysfunction
AT chinnaduraisaranya helicobacterpyloriinfectioninsystemicsclerosisanditsassociationwithuppergastrointestinaldysfunction
AT ramamoorthyramesh helicobacterpyloriinfectioninsystemicsclerosisanditsassociationwithuppergastrointestinaldysfunction
AT mayilsamysaravanan helicobacterpyloriinfectioninsystemicsclerosisanditsassociationwithuppergastrointestinaldysfunction
AT sankaralingamrajeswari helicobacterpyloriinfectioninsystemicsclerosisanditsassociationwithuppergastrointestinaldysfunction