Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy
Aim. To evaluate the safety and accuracy of percutaneous transhepatic biliary biopsy in patients with suspected Klatskin tumor.Materials and methods. Between 2013–2020, percutaneous transhepatic biliary drainage (PTBD) was performed in 52 patients with Klatskin tumor, complicated by obstructive jaun...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2022-08-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/610 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860085579841536 |
|---|---|
| author | A. V. Kozlov P. G. Tarazov A. A. Polikarpov A. V. Moiseenko A. I. Urbansky M. V. Yutkin G. M. Yakshieva D. A. Granov |
| author_facet | A. V. Kozlov P. G. Tarazov A. A. Polikarpov A. V. Moiseenko A. I. Urbansky M. V. Yutkin G. M. Yakshieva D. A. Granov |
| author_sort | A. V. Kozlov |
| collection | DOAJ |
| description | Aim. To evaluate the safety and accuracy of percutaneous transhepatic biliary biopsy in patients with suspected Klatskin tumor.Materials and methods. Between 2013–2020, percutaneous transhepatic biliary drainage (PTBD) was performed in 52 patients with Klatskin tumor, complicated by obstructive jaundice. After successful PTBD, the diagnosis was verified by antegrade access. 74 procedures were performed: brush (n = 36; 48.6 %) or forceps biopsies (n = 38; 51.4 %).Results. There were no adverse events associated with a brush biopsy. Only grade I complications were after the forceps technique: 3 patients (7.9 %) developed hemobilia, which was corrected conservatively. Malignant lesions of the biliary tract were detected by forceps technique in 79.0 %, brush biopsy in 66.7 % (p >0,05). The degree of tumor differentiation was determined in 60.0 % (n = 18) vs 12.5 % (n = 3) (p < 0,01), respectively.Sensitivity and specificity of forceps biopsy were slightly higher than in brush: 82.4 % and 75.0 % vs 73.3 % and 66.7 % (p >0,05).Conclusions. Antegrade percutaneous transhepatic biliary biopsy is safe for both brush and forceps techniques. However, forceps biopsy has higher sensitivity and specificity in the diagnosis Klatskin tumor and better possibility of determining the degree of malignancy differentiation. |
| format | Article |
| id | doaj-art-da4dd5075d9b48c0a6c703feb31e84f7 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2022-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-da4dd5075d9b48c0a6c703feb31e84f72025-02-10T16:14:37ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732022-08-01322455410.22416/1382-4376-2022-32-2-45-54480Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush BiopsyA. V. Kozlov0P. G. Tarazov1A. A. Polikarpov2A. V. Moiseenko3A. I. Urbansky4M. V. Yutkin5G. M. Yakshieva6D. A. Granov7Russian Scientific Center of Radiology and Surgical Technologies named after academician A.M. GranovRussian Scientific Center of Radiology and Surgical Technologies named after academician A.M. GranovRussian Scientific Center of Radiology and Surgical Technologies named after academician A.M. GranovRussian Scientific Center of Radiology and Surgical Technologies named after academician A.M. GranovRussian Scientific Center of Radiology and Surgical Technologies named after academician A.M. GranovRussian Scientific Center of Radiology and Surgical Technologies named after academician A.M. GranovFirst St. Petersburg State Medical University named after Academician I.P. PavlovRussian Scientific Center of Radiology and Surgical Technologies named after academician A.M. Granov; First St. Petersburg State Medical University named after Academician I.P. PavlovAim. To evaluate the safety and accuracy of percutaneous transhepatic biliary biopsy in patients with suspected Klatskin tumor.Materials and methods. Between 2013–2020, percutaneous transhepatic biliary drainage (PTBD) was performed in 52 patients with Klatskin tumor, complicated by obstructive jaundice. After successful PTBD, the diagnosis was verified by antegrade access. 74 procedures were performed: brush (n = 36; 48.6 %) or forceps biopsies (n = 38; 51.4 %).Results. There were no adverse events associated with a brush biopsy. Only grade I complications were after the forceps technique: 3 patients (7.9 %) developed hemobilia, which was corrected conservatively. Malignant lesions of the biliary tract were detected by forceps technique in 79.0 %, brush biopsy in 66.7 % (p >0,05). The degree of tumor differentiation was determined in 60.0 % (n = 18) vs 12.5 % (n = 3) (p < 0,01), respectively.Sensitivity and specificity of forceps biopsy were slightly higher than in brush: 82.4 % and 75.0 % vs 73.3 % and 66.7 % (p >0,05).Conclusions. Antegrade percutaneous transhepatic biliary biopsy is safe for both brush and forceps techniques. However, forceps biopsy has higher sensitivity and specificity in the diagnosis Klatskin tumor and better possibility of determining the degree of malignancy differentiation.https://www.gastro-j.ru/jour/article/view/610cholangiocarcinomaklatskin tumorbrush biopsyforceps biopsypercutaneous transhepatic biliary drainage |
| spellingShingle | A. V. Kozlov P. G. Tarazov A. A. Polikarpov A. V. Moiseenko A. I. Urbansky M. V. Yutkin G. M. Yakshieva D. A. Granov Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy Российский журнал гастроэнтерологии, гепатологии, колопроктологии cholangiocarcinoma klatskin tumor brush biopsy forceps biopsy percutaneous transhepatic biliary drainage |
| title | Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy |
| title_full | Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy |
| title_fullStr | Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy |
| title_full_unstemmed | Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy |
| title_short | Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy |
| title_sort | antegrade endobiliary forceps biopsy improves diagnosis of klatskin tumor compared to brush biopsy |
| topic | cholangiocarcinoma klatskin tumor brush biopsy forceps biopsy percutaneous transhepatic biliary drainage |
| url | https://www.gastro-j.ru/jour/article/view/610 |
| work_keys_str_mv | AT avkozlov antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy AT pgtarazov antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy AT aapolikarpov antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy AT avmoiseenko antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy AT aiurbansky antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy AT mvyutkin antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy AT gmyakshieva antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy AT dagranov antegradeendobiliaryforcepsbiopsyimprovesdiagnosisofklatskintumorcomparedtobrushbiopsy |