Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions
Kinetics of the acid hydrolysis of bromazepam (Bz) has been investigated in micelles, reverse micelles, and microemulcions of cetyltrimethylammonium bromide (CTAB) by spectrophotometric method. The rate of the acid hydrolysis of Bz was found to be enhanced both below and above the critical micelle c...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/957950 |
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| author | Ferdousi Begum M. Yousuf A. Mollah M. Muhibur Rahman Md. Abu Bin Hasan Susan |
| author_facet | Ferdousi Begum M. Yousuf A. Mollah M. Muhibur Rahman Md. Abu Bin Hasan Susan |
| author_sort | Ferdousi Begum |
| collection | DOAJ |
| description | Kinetics of the acid hydrolysis of bromazepam (Bz) has been investigated in micelles, reverse micelles, and microemulcions of cetyltrimethylammonium bromide (CTAB) by spectrophotometric method. The rate of the acid hydrolysis of Bz was found to be enhanced both below and above the critical micelle concentration (CMC) of CTAB in aqueous solution. The pseudo-first-order rate constant (k′) shows an initial decrease for both low and high H+ concentrations. With further increase in [CTAB], at low [H+], the k′ attains an almost constant value, while, at high [H+], the k′ passes through a maximum and then decreases. The kinetic data for catalysis by micelles of CTAB was interpreted with the pseudophase ion exchange (PIE) model. In CTAB/cyclohexane/1-butanol/water microemulsions, as the water to surfactant ratio (wo) increases, the physicochemical properties and droplet sizes of microemulsions significantly change and distinct changes in reaction environment can be marked. The rate of the hydrolysis reaction exhibits excellent correlation with the physicochemical properties and droplet sizes of the microemulsions and reverse micelles of CTAB. At [H+] = 0.001 M, in reverse micelles and microemulsions of CTAB, the k′ of the acid hydrolysis of Bz decreases sharply followed by a slight increase with increasing wo. |
| format | Article |
| id | doaj-art-da4be4f375ae49809b8ce5126391cd83 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-da4be4f375ae49809b8ce5126391cd832025-02-03T05:43:41ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/957950957950Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and MicroemulsionsFerdousi Begum0M. Yousuf A. Mollah1M. Muhibur Rahman2Md. Abu Bin Hasan Susan3Department of Chemistry, University of Dhaka, Dhaka 1000, BangladeshDepartment of Chemistry, University of Dhaka, Dhaka 1000, BangladeshUniversity Grants Commission of Bangladesh, 29/1 Agargaon, Dhaka 1207, BangladeshDepartment of Chemistry, University of Dhaka, Dhaka 1000, BangladeshKinetics of the acid hydrolysis of bromazepam (Bz) has been investigated in micelles, reverse micelles, and microemulcions of cetyltrimethylammonium bromide (CTAB) by spectrophotometric method. The rate of the acid hydrolysis of Bz was found to be enhanced both below and above the critical micelle concentration (CMC) of CTAB in aqueous solution. The pseudo-first-order rate constant (k′) shows an initial decrease for both low and high H+ concentrations. With further increase in [CTAB], at low [H+], the k′ attains an almost constant value, while, at high [H+], the k′ passes through a maximum and then decreases. The kinetic data for catalysis by micelles of CTAB was interpreted with the pseudophase ion exchange (PIE) model. In CTAB/cyclohexane/1-butanol/water microemulsions, as the water to surfactant ratio (wo) increases, the physicochemical properties and droplet sizes of microemulsions significantly change and distinct changes in reaction environment can be marked. The rate of the hydrolysis reaction exhibits excellent correlation with the physicochemical properties and droplet sizes of the microemulsions and reverse micelles of CTAB. At [H+] = 0.001 M, in reverse micelles and microemulsions of CTAB, the k′ of the acid hydrolysis of Bz decreases sharply followed by a slight increase with increasing wo.http://dx.doi.org/10.1155/2015/957950 |
| spellingShingle | Ferdousi Begum M. Yousuf A. Mollah M. Muhibur Rahman Md. Abu Bin Hasan Susan Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions Journal of Chemistry |
| title | Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions |
| title_full | Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions |
| title_fullStr | Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions |
| title_full_unstemmed | Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions |
| title_short | Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions |
| title_sort | acid hydrolysis of bromazepam catalyzed by micelles reverse micelles and microemulsions |
| url | http://dx.doi.org/10.1155/2015/957950 |
| work_keys_str_mv | AT ferdousibegum acidhydrolysisofbromazepamcatalyzedbymicellesreversemicellesandmicroemulsions AT myousufamollah acidhydrolysisofbromazepamcatalyzedbymicellesreversemicellesandmicroemulsions AT mmuhiburrahman acidhydrolysisofbromazepamcatalyzedbymicellesreversemicellesandmicroemulsions AT mdabubinhasansusan acidhydrolysisofbromazepamcatalyzedbymicellesreversemicellesandmicroemulsions |