Evobrutinib mitigates neuroinflammation after ischemic stroke by targeting M1 microglial polarization via the TLR4/Myd88/NF-κB pathway

Evobrutinib mitigates neuroinflammation after ischemic stroke by targeting M1 microglial polarization via the TLR4/Myd88/NF-κB pathway

Abstract Background Evobrutinib, a third-generation Bruton's tyrosine kinase (BTK) inhibitor, shows great promise for treating neuroinflammatory diseases due to its small molecular size, ease of absorption, and ability to cross the blood–brain barrier. Although previous studies have confirmed s...

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Main Authors: Yixiang Jiang, Ning Wang, Jingyi Liu, Jiayi Li, Lulu Chang, Changxin Yang, Zhengyi Chen, Wei Huang, Jing Wang, Xiujuan Lang, Xijun Liu, Yumei Liu, Bo Sun, Hulun Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Medicine
Subjects:
Evobrutinib
Cerebral ischemia
Therapy
Microglia polarization
Neuroinflammation
Online Access:https://doi.org/10.1186/s10020-025-01203-8
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