Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice
Hypertension is associated with alterations in the composition and diversity of the intestinal microbiota. Indeed, supplementation with probiotics and prebiotics has shown promising results in modulating the gut microbiota and improving cardiovascular health. However, there are no studies regarding...
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MDPI AG
2025-02-01
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| Series: | Antioxidants |
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| author | Mario de la Fuente-Muñoz Marta Román-Carmena Sara Amor Daniel González-Hedström Verónica Martinez-Rios Patricia Martorell Antonio M. Inarejos-García Reme García Bou Sonia Guilera-Bermell Ángel L. García-Villalón Miriam Granado |
| author_facet | Mario de la Fuente-Muñoz Marta Román-Carmena Sara Amor Daniel González-Hedström Verónica Martinez-Rios Patricia Martorell Antonio M. Inarejos-García Reme García Bou Sonia Guilera-Bermell Ángel L. García-Villalón Miriam Granado |
| author_sort | Mario de la Fuente-Muñoz |
| collection | DOAJ |
| description | Hypertension is associated with alterations in the composition and diversity of the intestinal microbiota. Indeed, supplementation with probiotics and prebiotics has shown promising results in modulating the gut microbiota and improving cardiovascular health. However, there are no studies regarding the possible beneficial effects of postbiotics on cardiovascular function and particularly on hypertension-induced cardiovascular alterations. Thus, the aim of this study was to analyze the effect of supplementation with the heat-treated <i>Bifidobacterium animalis</i> subsp. lactis CECT 8145 strain (BPL1™ HT), a postbiotic developed by the company ADM-Biopolis, on cardiovascular alterations induced by angiotensin II (AngII) infusion in mice. For this purpose, three groups of C57BL/6J male mice were used: (i) mice infused with saline (control); (ii) mice infused with AngII for 4 weeks (AngII); and (iii) mice supplemented with BPL1™ HT in the drinking water (1010 cells/animal/day) for 8 weeks and infused with AngII for the last 4 weeks (AngII + BPL1™ HT). AngII infusion was associated with heart hypertrophy, hypertension, endothelial dysfunction, and overexpression of proinflammatory cytokines in aortic tissue. BPL1™ HT supplementation reduced systolic blood pressure and attenuated AngII-induced endothelial dysfunction in aortic segments. Moreover, mice supplemented with BPL1™ HT showed a decreased gene expression of the proinflammatory cytokine interleukin 6 (<i>Il-6</i>) and the prooxidant enzymes NADPH oxidases 1 (<i>Nox-1</i>) and 4 (<i>Nox-4</i>), as well as an overexpression of AngII receptor 2 (<i>At2r</i>) and interleukin 10 (<i>Il-10</i>) in arterial tissue. In the heart, BPL1™ HT supplementation increased myocardial contractility and prevented ischemia–reperfusion-induced cardiomyocyte apoptosis. In conclusion, supplementation with the postbiotic BPL1™ HT prevents endothelial dysfunction, lowers blood pressure, and has cardioprotective effects in an experimental model of hypertension induced by AngII infusion in mice. |
| format | Article |
| id | doaj-art-da4ac36cdc7941d28e278aee9d72b60e |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-da4ac36cdc7941d28e278aee9d72b60e2025-08-20T02:44:40ZengMDPI AGAntioxidants2076-39212025-02-0114219310.3390/antiox14020193Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in MiceMario de la Fuente-Muñoz0Marta Román-Carmena1Sara Amor2Daniel González-Hedström3Verónica Martinez-Rios4Patricia Martorell5Antonio M. Inarejos-García6Reme García Bou7Sonia Guilera-Bermell8Ángel L. García-Villalón9Miriam Granado10Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainR&D Department of Functional Extracts, ADM<sup>®</sup> Valencia, 46740 Carcaixent, SpainR&D Department of Functional Extracts, ADM<sup>®</sup> Valencia, 46740 Carcaixent, SpainNutrition Archer Daniels Midland (ADM) Health & Wellness, Biopolis S. L. Parc Cientific, Universitat de València, 46980 Paterna, SpainR&D Department of Functional Extracts, ADM<sup>®</sup> Valencia, 46740 Carcaixent, SpainR&D Department of Functional Extracts, ADM<sup>®</sup> Valencia, 46740 Carcaixent, SpainR&D Department of Functional Extracts, ADM<sup>®</sup> Valencia, 46740 Carcaixent, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainHypertension is associated with alterations in the composition and diversity of the intestinal microbiota. Indeed, supplementation with probiotics and prebiotics has shown promising results in modulating the gut microbiota and improving cardiovascular health. However, there are no studies regarding the possible beneficial effects of postbiotics on cardiovascular function and particularly on hypertension-induced cardiovascular alterations. Thus, the aim of this study was to analyze the effect of supplementation with the heat-treated <i>Bifidobacterium animalis</i> subsp. lactis CECT 8145 strain (BPL1™ HT), a postbiotic developed by the company ADM-Biopolis, on cardiovascular alterations induced by angiotensin II (AngII) infusion in mice. For this purpose, three groups of C57BL/6J male mice were used: (i) mice infused with saline (control); (ii) mice infused with AngII for 4 weeks (AngII); and (iii) mice supplemented with BPL1™ HT in the drinking water (1010 cells/animal/day) for 8 weeks and infused with AngII for the last 4 weeks (AngII + BPL1™ HT). AngII infusion was associated with heart hypertrophy, hypertension, endothelial dysfunction, and overexpression of proinflammatory cytokines in aortic tissue. BPL1™ HT supplementation reduced systolic blood pressure and attenuated AngII-induced endothelial dysfunction in aortic segments. Moreover, mice supplemented with BPL1™ HT showed a decreased gene expression of the proinflammatory cytokine interleukin 6 (<i>Il-6</i>) and the prooxidant enzymes NADPH oxidases 1 (<i>Nox-1</i>) and 4 (<i>Nox-4</i>), as well as an overexpression of AngII receptor 2 (<i>At2r</i>) and interleukin 10 (<i>Il-10</i>) in arterial tissue. In the heart, BPL1™ HT supplementation increased myocardial contractility and prevented ischemia–reperfusion-induced cardiomyocyte apoptosis. In conclusion, supplementation with the postbiotic BPL1™ HT prevents endothelial dysfunction, lowers blood pressure, and has cardioprotective effects in an experimental model of hypertension induced by AngII infusion in mice.https://www.mdpi.com/2076-3921/14/2/193angiotensin IIhypertensioncardiovascular damagepostbioticantioxidantinflammation |
| spellingShingle | Mario de la Fuente-Muñoz Marta Román-Carmena Sara Amor Daniel González-Hedström Verónica Martinez-Rios Patricia Martorell Antonio M. Inarejos-García Reme García Bou Sonia Guilera-Bermell Ángel L. García-Villalón Miriam Granado Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice Antioxidants angiotensin II hypertension cardiovascular damage postbiotic antioxidant inflammation |
| title | Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice |
| title_full | Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice |
| title_fullStr | Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice |
| title_full_unstemmed | Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice |
| title_short | Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice |
| title_sort | supplementation with the postbiotic bpl1™ ht heat inactivated i bifidobacterium animalis i subsp lactis attenuates the cardiovascular alterations induced by angiotensin ii infusion in mice |
| topic | angiotensin II hypertension cardiovascular damage postbiotic antioxidant inflammation |
| url | https://www.mdpi.com/2076-3921/14/2/193 |
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