Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil
Mycophenolate mofetil (MMF) is associated with various gastrointestinal toxicities. However, limited literature studies exist reporting MMF-related gastrointestinal toxicity manifesting as esophageal strictures. We report a case of a 62-year-old male with kidney transplant on MMF, tacrolimus, and pr...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/8817801 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166468553998336 |
|---|---|
| author | Joyce J. Kim Ramzi H. Mulki Kavya M. Sebastian |
| author_facet | Joyce J. Kim Ramzi H. Mulki Kavya M. Sebastian |
| author_sort | Joyce J. Kim |
| collection | DOAJ |
| description | Mycophenolate mofetil (MMF) is associated with various gastrointestinal toxicities. However, limited literature studies exist reporting MMF-related gastrointestinal toxicity manifesting as esophageal strictures. We report a case of a 62-year-old male with kidney transplant on MMF, tacrolimus, and prednisone, presenting with progressive dysphagia and odynophagia. Esophagogastroduodenoscopy revealed severe esophageal stricturing with near food bolus impaction, requiring dilations, esophageal stent, and ultimately gastrostomy tube. Biopsies revealed nonspecific inflammation with no evidence of infectious/neoplastic process; thus, our multidisciplinary esophageal group determined that the process was secondary to MMF. This case demonstrates that, though rare, MMF can result in severe esophageal strictures causing significant morbidity. |
| format | Article |
| id | doaj-art-da42775afb7b410d885255b0007daefa |
| institution | OA Journals |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-da42775afb7b410d885255b0007daefa2025-08-20T02:21:25ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362020-01-01202010.1155/2020/88178018817801Recalcitrant Esophageal Stricture Secondary to Mycophenolate MofetilJoyce J. Kim0Ramzi H. Mulki1Kavya M. Sebastian2Department of Medicine, Emory University School of Medicine, Atlanta, GeorgiaDepartment of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GeorgiaDepartment of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GeorgiaMycophenolate mofetil (MMF) is associated with various gastrointestinal toxicities. However, limited literature studies exist reporting MMF-related gastrointestinal toxicity manifesting as esophageal strictures. We report a case of a 62-year-old male with kidney transplant on MMF, tacrolimus, and prednisone, presenting with progressive dysphagia and odynophagia. Esophagogastroduodenoscopy revealed severe esophageal stricturing with near food bolus impaction, requiring dilations, esophageal stent, and ultimately gastrostomy tube. Biopsies revealed nonspecific inflammation with no evidence of infectious/neoplastic process; thus, our multidisciplinary esophageal group determined that the process was secondary to MMF. This case demonstrates that, though rare, MMF can result in severe esophageal strictures causing significant morbidity.http://dx.doi.org/10.1155/2020/8817801 |
| spellingShingle | Joyce J. Kim Ramzi H. Mulki Kavya M. Sebastian Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil Case Reports in Gastrointestinal Medicine |
| title | Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil |
| title_full | Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil |
| title_fullStr | Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil |
| title_full_unstemmed | Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil |
| title_short | Recalcitrant Esophageal Stricture Secondary to Mycophenolate Mofetil |
| title_sort | recalcitrant esophageal stricture secondary to mycophenolate mofetil |
| url | http://dx.doi.org/10.1155/2020/8817801 |
| work_keys_str_mv | AT joycejkim recalcitrantesophagealstricturesecondarytomycophenolatemofetil AT ramzihmulki recalcitrantesophagealstricturesecondarytomycophenolatemofetil AT kavyamsebastian recalcitrantesophagealstricturesecondarytomycophenolatemofetil |