The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
Pluripotent stem cells give rise to reproductively enabled offsprings by generating progressively lineage-restricted multipotent stem cells that would differentiate into lineage-committed stem and progenitor cells. These lineage-committed stem and progenitor cells give rise to all adult tissues and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/1608787 |
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| author | Bertal H. Aktas Berin Upcin Erik Henke Manju Padmasekar Xuebin Qin Süleyman Ergün |
| author_facet | Bertal H. Aktas Berin Upcin Erik Henke Manju Padmasekar Xuebin Qin Süleyman Ergün |
| author_sort | Bertal H. Aktas |
| collection | DOAJ |
| description | Pluripotent stem cells give rise to reproductively enabled offsprings by generating progressively lineage-restricted multipotent stem cells that would differentiate into lineage-committed stem and progenitor cells. These lineage-committed stem and progenitor cells give rise to all adult tissues and organs. Adult stem and progenitor cells are generated as part of the developmental program and play critical roles in tissue and organ maintenance and/or regeneration. The ability of pluripotent stem cells to self-renew, maintain pluripotency, and differentiate into a multicellular organism is highly dependent on sensing and integrating extracellular and extraorganismal cues. Proteins perform and integrate almost all cellular functions including signal transduction, regulation of gene expression, metabolism, and cell division and death. Therefore, maintenance of an appropriate mix of correctly folded proteins, a pristine proteome, is essential for proper stem cell function. The stem cells’ proteome must be pristine because unfolded, misfolded, or otherwise damaged proteins would interfere with unlimited self-renewal, maintenance of pluripotency, differentiation into downstream lineages, and consequently with the development of properly functioning tissue and organs. Understanding how various stem cells generate and maintain a pristine proteome is therefore essential for exploiting their potential in regenerative medicine and possibly for the discovery of novel approaches for maintaining, propagating, and differentiating pluripotent, multipotent, and adult stem cells as well as induced pluripotent stem cells. In this review, we will summarize cellular networks used by various stem cells for generation and maintenance of a pristine proteome. We will also explore the coordination of these networks with one another and their integration with the gene regulatory and signaling networks. |
| format | Article |
| id | doaj-art-da41e36d0fa144f692a1382e1b89fc1b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-da41e36d0fa144f692a1382e1b89fc1b2025-08-20T03:24:25ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/16087871608787The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor CellsBertal H. Aktas0Berin Upcin1Erik Henke2Manju Padmasekar3Xuebin Qin4Süleyman Ergün5Division of Hematology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USAInstitute of Anatomy and Cell Biology, Julius-Maximilians Universität Würzburg, Koellikerstrasse 6, Würzburg, 97070 Bayern, GermanyInstitute of Anatomy and Cell Biology, Julius-Maximilians Universität Würzburg, Koellikerstrasse 6, Würzburg, 97070 Bayern, GermanyInstitute of Anatomy and Cell Biology, Julius-Maximilians Universität Würzburg, Koellikerstrasse 6, Würzburg, 97070 Bayern, GermanyDepartment of Neurology, Temple University, Philadelphia, USAInstitute of Anatomy and Cell Biology, Julius-Maximilians Universität Würzburg, Koellikerstrasse 6, Würzburg, 97070 Bayern, GermanyPluripotent stem cells give rise to reproductively enabled offsprings by generating progressively lineage-restricted multipotent stem cells that would differentiate into lineage-committed stem and progenitor cells. These lineage-committed stem and progenitor cells give rise to all adult tissues and organs. Adult stem and progenitor cells are generated as part of the developmental program and play critical roles in tissue and organ maintenance and/or regeneration. The ability of pluripotent stem cells to self-renew, maintain pluripotency, and differentiate into a multicellular organism is highly dependent on sensing and integrating extracellular and extraorganismal cues. Proteins perform and integrate almost all cellular functions including signal transduction, regulation of gene expression, metabolism, and cell division and death. Therefore, maintenance of an appropriate mix of correctly folded proteins, a pristine proteome, is essential for proper stem cell function. The stem cells’ proteome must be pristine because unfolded, misfolded, or otherwise damaged proteins would interfere with unlimited self-renewal, maintenance of pluripotency, differentiation into downstream lineages, and consequently with the development of properly functioning tissue and organs. Understanding how various stem cells generate and maintain a pristine proteome is therefore essential for exploiting their potential in regenerative medicine and possibly for the discovery of novel approaches for maintaining, propagating, and differentiating pluripotent, multipotent, and adult stem cells as well as induced pluripotent stem cells. In this review, we will summarize cellular networks used by various stem cells for generation and maintenance of a pristine proteome. We will also explore the coordination of these networks with one another and their integration with the gene regulatory and signaling networks.http://dx.doi.org/10.1155/2019/1608787 |
| spellingShingle | Bertal H. Aktas Berin Upcin Erik Henke Manju Padmasekar Xuebin Qin Süleyman Ergün The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells Stem Cells International |
| title | The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells |
| title_full | The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells |
| title_fullStr | The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells |
| title_full_unstemmed | The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells |
| title_short | The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells |
| title_sort | best for the most important maintaining a pristine proteome in stem and progenitor cells |
| url | http://dx.doi.org/10.1155/2019/1608787 |
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