IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection
The role of cytokines in relation to clinical manifestations, disease severity, and outcome of children with H1N1 virus infection remains thus far unclear. The aim of this study was to evaluate interleukin IL-1β and IL-6 plasma expressions and their association with clinical findings, disease severi...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/495848 |
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| author | Antonio Chiaretti Silvia Pulitanò Giovanni Barone Pietro Ferrara Valerio Romano Domenico Capozzi Riccardo Riccardi |
| author_facet | Antonio Chiaretti Silvia Pulitanò Giovanni Barone Pietro Ferrara Valerio Romano Domenico Capozzi Riccardo Riccardi |
| author_sort | Antonio Chiaretti |
| collection | DOAJ |
| description | The role of cytokines in relation to clinical manifestations, disease severity, and outcome of children with H1N1 virus infection remains thus far unclear. The aim of this study was to evaluate interleukin IL-1β and IL-6 plasma expressions and their association with clinical findings, disease severity, and outcome of children with H1N1 infection. We prospectively evaluated 15 children with H1N1 virus infection and 15 controls with lower respiratory tract infections (LRTI). Interleukin plasma levels were measured using immunoenzymatic assays. Significantly higher levels of IL-1β and IL-6 were detected in all patients with H1N1 virus infection compared to controls. It is noteworthy to mention that in H1N1 patients with more severe clinical manifestations of disease IL-1β and IL-6 expressions were significantly upregulated compared to H1N1 patients with mild clinical manifestations. In particular, IL-6 was significantly correlated with specific clinical findings, such as severity of respiratory compromise and fever. No correlation was found between interleukin expression and final outcome. In conclusion, H1N1 virus infection induces an early and significant upregulation of both interleukins IL1β and IL-6 plasma expressions. The upregulation of these cytokines is likely to play a proinflammatory role in H1N1 virus infection and may contribute to airway inflammation and bronchial hyperreactivity in these patients. |
| format | Article |
| id | doaj-art-da3e673740a24d14a5dcdf4f018b5be4 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-da3e673740a24d14a5dcdf4f018b5be42025-08-20T02:21:11ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/495848495848IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus InfectionAntonio Chiaretti0Silvia Pulitanò1Giovanni Barone2Pietro Ferrara3Valerio Romano4Domenico Capozzi5Riccardo Riccardi6Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Policlinico Gemelli, Largo Gemelli, 1-00168 Rome, ItalyPediatric Intensive Care Unit, Catholic University of the Sacred Heart, A. Gemelli Hospital, 00168 Rome, ItalyDepartment of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Policlinico Gemelli, Largo Gemelli, 1-00168 Rome, ItalyDepartment of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Policlinico Gemelli, Largo Gemelli, 1-00168 Rome, ItalyDepartment of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Policlinico Gemelli, Largo Gemelli, 1-00168 Rome, ItalyDepartment of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Policlinico Gemelli, Largo Gemelli, 1-00168 Rome, ItalyDepartment of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Policlinico Gemelli, Largo Gemelli, 1-00168 Rome, ItalyThe role of cytokines in relation to clinical manifestations, disease severity, and outcome of children with H1N1 virus infection remains thus far unclear. The aim of this study was to evaluate interleukin IL-1β and IL-6 plasma expressions and their association with clinical findings, disease severity, and outcome of children with H1N1 infection. We prospectively evaluated 15 children with H1N1 virus infection and 15 controls with lower respiratory tract infections (LRTI). Interleukin plasma levels were measured using immunoenzymatic assays. Significantly higher levels of IL-1β and IL-6 were detected in all patients with H1N1 virus infection compared to controls. It is noteworthy to mention that in H1N1 patients with more severe clinical manifestations of disease IL-1β and IL-6 expressions were significantly upregulated compared to H1N1 patients with mild clinical manifestations. In particular, IL-6 was significantly correlated with specific clinical findings, such as severity of respiratory compromise and fever. No correlation was found between interleukin expression and final outcome. In conclusion, H1N1 virus infection induces an early and significant upregulation of both interleukins IL1β and IL-6 plasma expressions. The upregulation of these cytokines is likely to play a proinflammatory role in H1N1 virus infection and may contribute to airway inflammation and bronchial hyperreactivity in these patients.http://dx.doi.org/10.1155/2013/495848 |
| spellingShingle | Antonio Chiaretti Silvia Pulitanò Giovanni Barone Pietro Ferrara Valerio Romano Domenico Capozzi Riccardo Riccardi IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection Mediators of Inflammation |
| title | IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection |
| title_full | IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection |
| title_fullStr | IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection |
| title_full_unstemmed | IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection |
| title_short | IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection |
| title_sort | il 1β and il 6 upregulation in children with h1n1 influenza virus infection |
| url | http://dx.doi.org/10.1155/2013/495848 |
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