Mannose binding lectin as a marker for coronary artery disease in hypertension
Background According to The Framingham Heart Study and the Epidemiology of Cardiovascular Diseases hypertension is an independent risk factor for cardiovascular disease (1). Inflammation plays a major role in atherosclerosis. Markers of innate immunity have been shown to predict the devel...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Makhdoomi Printers
2025-04-01
|
| Series: | Global Journal of Medicine and Public Health |
| Subjects: | |
| Online Access: | https://nicpd.ac.in/ojs-/index.php/gjmedph/article/view/4127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background
According to The Framingham Heart Study and the Epidemiology of Cardiovascular Diseases hypertension is an
independent risk factor for cardiovascular disease (1). Inflammation plays a major role in atherosclerosis. Markers
of innate immunity have been shown to predict the development of coronary artery disease. MBL (Mannose binding
lectin) being a component of innate immunity can be used as a marker of cardiovascular risk in hypertension.
Aim & Objectives:
The study was conducted to evaluate the risk of coronary artery disease in recently diagnosed hypertensive patients
by estimating serum mannose binding lectin levels
Materials & Methods:
This cross sectional case control study was conducted among 180 subjects who were divided into three groups as
follows
Group A : 60 recently diagnosed hypertensive patients ( < 6 months duration )
Group B : 60 hypertensive patients who had myocardial infarction recently (< 7 days)
Group C : 60 age & sex matched healthy controls
Serum levels of MBL was evaluated in the three groups using ELISA technique. Collected data were analysed
statistically.
Results & Conclusion:
The serum MBL levels were significantly elevated in hypertensive patients (mean = 823.45 ng/mL; Range – 772 to
875 ng/mL) and in hypertensive with myocardial infarction (mean = 1163.39 ng/mL; Range – 945 to 1381 ng/mL) as
compared with control population (mean = 607.15 ng/mL; Range – 513 to 701 ng/mL) with p value of 0.001. From
the ROC curve, it has been determined that MBL has sensitivity of 93% & specificity of 96%) with a positive
predictive value of 96% & negative predictive value of 84.65%.
Our findings suggested the determination of MBL status may serve as a potential marker for early identification of
patients at risk of cardiovascular complications, pending further validation studies.
|
|---|---|
| ISSN: | 2277-9604 |