Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience
Abstract Psychedelics offer a profound window into the human brain through their robust effects on perception, subjective experience, and brain activity patterns. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) induces a profoundly immersive altered state of consciousness lasting under 20 ...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08078-9 |
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| author | S. Parker Singleton Christopher Timmermann Andrea I. Luppi Emma Eckernäs Leor Roseman Robin L. Carhart-Harris Amy Kuceyeski |
| author_facet | S. Parker Singleton Christopher Timmermann Andrea I. Luppi Emma Eckernäs Leor Roseman Robin L. Carhart-Harris Amy Kuceyeski |
| author_sort | S. Parker Singleton |
| collection | DOAJ |
| description | Abstract Psychedelics offer a profound window into the human brain through their robust effects on perception, subjective experience, and brain activity patterns. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) induces a profoundly immersive altered state of consciousness lasting under 20 min, allowing the entire experience to be captured during a single functional magnetic resonance imaging (fMRI) scan. Using network control theory, we map energy trajectories of 14 individuals undergoing fMRI during DMT and placebo. We find that global control energy is reduced after DMT injection compared to placebo. Longitudinal trajectories of global control energy correlate with longitudinal trajectories of electroencephalography (EEG) signal diversity (a measure of entropy) and subjective drug intensity ratings. At the regional level, spatial patterns of DMT’s effects on these metrics correlate with serotonin 2a receptor density from positron emission tomography (PET) data. Using receptor distribution and pharmacokinetic information, we recapitulate DMT’s effects on global control energy trajectories, demonstrating control models can predict pharmacological effects on brain dynamics. |
| format | Article |
| id | doaj-art-da2ff8dbe9bd408fb80fd4577289501e |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-da2ff8dbe9bd408fb80fd4577289501e2025-08-20T02:28:10ZengNature PortfolioCommunications Biology2399-36422025-04-018111310.1038/s42003-025-08078-9Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experienceS. Parker Singleton0Christopher Timmermann1Andrea I. Luppi2Emma Eckernäs3Leor Roseman4Robin L. Carhart-Harris5Amy Kuceyeski6Department of Computational Biology, Cornell UniversityCenter for Psychedelic Research, Department of Brain Science, Imperial College LondonMontreal Neurological InstituteUnit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at University of GothenburgCenter for Psychedelic Research, Department of Brain Science, Imperial College LondonCenter for Psychedelic Research, Department of Brain Science, Imperial College LondonDepartment of Computational Biology, Cornell UniversityAbstract Psychedelics offer a profound window into the human brain through their robust effects on perception, subjective experience, and brain activity patterns. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) induces a profoundly immersive altered state of consciousness lasting under 20 min, allowing the entire experience to be captured during a single functional magnetic resonance imaging (fMRI) scan. Using network control theory, we map energy trajectories of 14 individuals undergoing fMRI during DMT and placebo. We find that global control energy is reduced after DMT injection compared to placebo. Longitudinal trajectories of global control energy correlate with longitudinal trajectories of electroencephalography (EEG) signal diversity (a measure of entropy) and subjective drug intensity ratings. At the regional level, spatial patterns of DMT’s effects on these metrics correlate with serotonin 2a receptor density from positron emission tomography (PET) data. Using receptor distribution and pharmacokinetic information, we recapitulate DMT’s effects on global control energy trajectories, demonstrating control models can predict pharmacological effects on brain dynamics.https://doi.org/10.1038/s42003-025-08078-9 |
| spellingShingle | S. Parker Singleton Christopher Timmermann Andrea I. Luppi Emma Eckernäs Leor Roseman Robin L. Carhart-Harris Amy Kuceyeski Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience Communications Biology |
| title | Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience |
| title_full | Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience |
| title_fullStr | Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience |
| title_full_unstemmed | Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience |
| title_short | Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience |
| title_sort | network control energy reductions under dmt relate to serotonin receptors signal diversity and subjective experience |
| url | https://doi.org/10.1038/s42003-025-08078-9 |
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