Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner
Alcohol use disorder (AUD) is strongly associated with initiation of drinking during adolescence. Little is known about neural mechanisms that produce the long-term detrimental effects of adolescent drinking. A critical feature of AUD is deficits in response inhibition, or the ability to withhold a...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929325000477 |
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| author | Aqilah M. McCane Lo Kronheim Bita Moghaddam |
| author_facet | Aqilah M. McCane Lo Kronheim Bita Moghaddam |
| author_sort | Aqilah M. McCane |
| collection | DOAJ |
| description | Alcohol use disorder (AUD) is strongly associated with initiation of drinking during adolescence. Little is known about neural mechanisms that produce the long-term detrimental effects of adolescent drinking. A critical feature of AUD is deficits in response inhibition, or the ability to withhold a reward-seeking response. Here, we sought to determine if adolescent drinking affects response inhibition and encoding of neural events by the orbitofrontal cortex (OFC) and dorsomedial striatum (DMS), two regions critical for expression of response inhibition. Adolescent male and female rats were given access to alcohol for four hours a day for five consecutive days. Then, rats were tested in a cued response inhibition task as adolescents or adults while we recorded concomitantly from the OFC and DMS. Adolescent voluntary alcohol drinking impaired response inhibition and increased alcohol drinking in male but not female rats. Adolescent alcohol drinking was associated with reduced excitation following premature actions in adults and increased OFC-DMS synchrony in male but not female rats. Collectively, these data suggest sex-specific effects of adolescent alcohol drinking on response inhibition and corresponding alterations in cortical-striatal circuitry. |
| format | Article |
| id | doaj-art-da2b9aa3ee074b7fa85c2e89c6ba8134 |
| institution | DOAJ |
| issn | 1878-9293 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj-art-da2b9aa3ee074b7fa85c2e89c6ba81342025-08-20T02:40:29ZengElsevierDevelopmental Cognitive Neuroscience1878-92932025-06-017310155210.1016/j.dcn.2025.101552Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific mannerAqilah M. McCane0Lo Kronheim1Bita Moghaddam2Corresponding author.; Oregon Health and Science University, Portland, OR, United StatesOregon Health and Science University, Portland, OR, United StatesOregon Health and Science University, Portland, OR, United StatesAlcohol use disorder (AUD) is strongly associated with initiation of drinking during adolescence. Little is known about neural mechanisms that produce the long-term detrimental effects of adolescent drinking. A critical feature of AUD is deficits in response inhibition, or the ability to withhold a reward-seeking response. Here, we sought to determine if adolescent drinking affects response inhibition and encoding of neural events by the orbitofrontal cortex (OFC) and dorsomedial striatum (DMS), two regions critical for expression of response inhibition. Adolescent male and female rats were given access to alcohol for four hours a day for five consecutive days. Then, rats were tested in a cued response inhibition task as adolescents or adults while we recorded concomitantly from the OFC and DMS. Adolescent voluntary alcohol drinking impaired response inhibition and increased alcohol drinking in male but not female rats. Adolescent alcohol drinking was associated with reduced excitation following premature actions in adults and increased OFC-DMS synchrony in male but not female rats. Collectively, these data suggest sex-specific effects of adolescent alcohol drinking on response inhibition and corresponding alterations in cortical-striatal circuitry.http://www.sciencedirect.com/science/article/pii/S1878929325000477Dorsal striatumElectrophysiologyLocal field potentialDevelopmentEthanolFrontal cortex |
| spellingShingle | Aqilah M. McCane Lo Kronheim Bita Moghaddam Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner Developmental Cognitive Neuroscience Dorsal striatum Electrophysiology Local field potential Development Ethanol Frontal cortex |
| title | Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner |
| title_full | Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner |
| title_fullStr | Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner |
| title_full_unstemmed | Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner |
| title_short | Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner |
| title_sort | adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal striatal activity in a sex specific manner |
| topic | Dorsal striatum Electrophysiology Local field potential Development Ethanol Frontal cortex |
| url | http://www.sciencedirect.com/science/article/pii/S1878929325000477 |
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