The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients
<b>Purpose</b>: Living-donor liver transplantation (LDLT) serves as a solution for patients facing end-stage liver disease. The existing literature indicates that sex differences between transplant donors and recipients might influence survival rates. <b>Methods</b>: We used...
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MDPI AG
2025-03-01
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| author | Mei-Yun Wu Yu-Hung Lin Wei-Juo Tzeng Shih-Feng Weng Wan-Ching Chang Chich-Hsiu Hung |
| author_facet | Mei-Yun Wu Yu-Hung Lin Wei-Juo Tzeng Shih-Feng Weng Wan-Ching Chang Chich-Hsiu Hung |
| author_sort | Mei-Yun Wu |
| collection | DOAJ |
| description | <b>Purpose</b>: Living-donor liver transplantation (LDLT) serves as a solution for patients facing end-stage liver disease. The existing literature indicates that sex differences between transplant donors and recipients might influence survival rates. <b>Methods</b>: We used a retrospective study design to investigate the impact of different sex pairings on the survival rates of adult LDLT recipients. This study involved the long-term tracking of recipients who underwent LDLT between 7 June 2000 and 31 December 2021. <b>Results</b>: In total, 169 pairs (37.1%) of male recipients with male donors, 145 pairs (31.8%) of male recipients with female donors, 77 pairs (16.9%) of female recipients with female donors, and 65 pairs (14.3%) of female recipients with male donors were submitted for analysis. With independent <i>t</i>-tests or chi-squared tests demonstrating that liver weight and graft-to-recipient weight ratio (GRWR) for same-sex LDLT recipients were significantly higher than opposite-sex recipients; significant differences in disease diagnoses between same-sex and opposite-sex LDLT recipients were found. The Kaplan–Meier survival curve indicates that while same-sex pair survival rates were higher than opposite-sex pairs, the difference was not statistically significant. <b>Conclusions</b>: While sex matching might have some impact on survival rates, it is influenced by a variety of factors, so the effects of donor and recipient sex matching on liver transplantation remains controversial. The findings of this study can serve as a reference for living-donor liver transplant teams when making donor selection decisions. |
| format | Article |
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| issn | 2075-4418 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-da2b7c49495e487cad6048f80c466ab12025-08-20T02:11:12ZengMDPI AGDiagnostics2075-44182025-03-0115675710.3390/diagnostics15060757The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex RecipientsMei-Yun Wu0Yu-Hung Lin1Wei-Juo Tzeng2Shih-Feng Weng3Wan-Ching Chang4Chich-Hsiu Hung5School of Nursing, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Health Care Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanSchool of Nursing, Kaohsiung Medical University, Kaohsiung 807, Taiwan<b>Purpose</b>: Living-donor liver transplantation (LDLT) serves as a solution for patients facing end-stage liver disease. The existing literature indicates that sex differences between transplant donors and recipients might influence survival rates. <b>Methods</b>: We used a retrospective study design to investigate the impact of different sex pairings on the survival rates of adult LDLT recipients. This study involved the long-term tracking of recipients who underwent LDLT between 7 June 2000 and 31 December 2021. <b>Results</b>: In total, 169 pairs (37.1%) of male recipients with male donors, 145 pairs (31.8%) of male recipients with female donors, 77 pairs (16.9%) of female recipients with female donors, and 65 pairs (14.3%) of female recipients with male donors were submitted for analysis. With independent <i>t</i>-tests or chi-squared tests demonstrating that liver weight and graft-to-recipient weight ratio (GRWR) for same-sex LDLT recipients were significantly higher than opposite-sex recipients; significant differences in disease diagnoses between same-sex and opposite-sex LDLT recipients were found. The Kaplan–Meier survival curve indicates that while same-sex pair survival rates were higher than opposite-sex pairs, the difference was not statistically significant. <b>Conclusions</b>: While sex matching might have some impact on survival rates, it is influenced by a variety of factors, so the effects of donor and recipient sex matching on liver transplantation remains controversial. The findings of this study can serve as a reference for living-donor liver transplant teams when making donor selection decisions.https://www.mdpi.com/2075-4418/15/6/757liver transplantationliving-donor liver transplantationsex matchingsurvival rates |
| spellingShingle | Mei-Yun Wu Yu-Hung Lin Wei-Juo Tzeng Shih-Feng Weng Wan-Ching Chang Chich-Hsiu Hung The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients Diagnostics liver transplantation living-donor liver transplantation sex matching survival rates |
| title | The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients |
| title_full | The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients |
| title_fullStr | The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients |
| title_full_unstemmed | The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients |
| title_short | The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients |
| title_sort | survival rate of living donor liver transplantation between same sex and opposite sex recipients |
| topic | liver transplantation living-donor liver transplantation sex matching survival rates |
| url | https://www.mdpi.com/2075-4418/15/6/757 |
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