Evaluating the factors influencing accuracy, interpretability, and reproducibility in the use of machine learning classifiers in biology to enable standardization

Abstract The complexity and variability of biological data has promoted the increased use of machine learning methods to understand processes and predict outcomes. These same features complicate reliable, reproducible, interpretable, and responsible use of such methods, resulting in questionable rel...

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Bibliographic Details
Main Authors: Kaitlyn M. Martinez, Kristen Wilding, Trent R. Llewellyn, Daniel E. Jacobsen, Makaela M. Montoya, Jessica Z. Kubicek-Sutherland, Sweta Batni, Carrie Manore, Harshini Mukundan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-00245-6
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