A Single-Chain Variable Fragment Antibody Alleviates Inflammation and Apoptosis of Neurons by Inhibiting Tau Aggregation

A Single-Chain Variable Fragment Antibody Alleviates Inflammation and Apoptosis of Neurons by Inhibiting Tau Aggregation

Tau pathology is one of the main pathological features of Alzheimer’s disease (AD). Intracellular Tau may be released to the extracellular space upon neuron degeneration, where it has the potential to be toxic to other neurons. The propagation of Tau pathology, mediated by extracellular Tau aggregat...

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Bibliographic Details
Main Authors: Zongbao Wang, Jingye Lin, Peipei Chang, Mingzhu Sun, Sen Li
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
Alzheimer’s disease
extracellular Tau aggregates
single-chain variable fragment antibody
ROS
Online Access:https://www.mdpi.com/2218-273X/15/6/872
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