Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention
Abstract At present, cardiovascular infection such as infective endocarditis (IE) has become a major disease with a high mortality rate. The essence of IE is actually the infection associated with biofilm formation, which can occur not only on native heart valves, but also on prosthetic heart valves...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | MedComm – Biomaterials and Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mba2.70003 |
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| _version_ | 1850096671402229760 |
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| author | Qi Tong Qiyue Xu Jie Cai Yiren Sun Zhengjie Wang Yongjun Qian |
| author_facet | Qi Tong Qiyue Xu Jie Cai Yiren Sun Zhengjie Wang Yongjun Qian |
| author_sort | Qi Tong |
| collection | DOAJ |
| description | Abstract At present, cardiovascular infection such as infective endocarditis (IE) has become a major disease with a high mortality rate. The essence of IE is actually the infection associated with biofilm formation, which can occur not only on native heart valves, but also on prosthetic heart valves and cardiovascular implants such as left heart assist devices, vascular grafts, and pacemakers. Biofilms are bacterial aggregates that are composed of a self‐produced extracellular polymeric substance (EPS), which is difficult and challenging for the treatment of cardiovascular infections. Therefore, it is important to explore and develop effective anti‐biofilm methods for the treatment of biofilm‐associated cardiovascular infection. This review provides comprehension of strategies for degrading EPS in biofilm, the application of nanodrug delivery systems for biofilm‐related infections, the strategy for targeting drug resistance genes through gene editing technology and strategy for targeting quorum sensing in biofilm. Furthermore, this review also provides some strategies to optimize the antibacterial properties of cardiovascular implants to prevent biofilm formation. The applications of these strategies will provide novel preventive and therapeutic ways for biofilm‐associated cardiovascular infections. |
| format | Article |
| id | doaj-art-da26c80d892d49b7af91afa990b754a5 |
| institution | DOAJ |
| issn | 2769-643X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Biomaterials and Applications |
| spelling | doaj-art-da26c80d892d49b7af91afa990b754a52025-08-20T02:41:10ZengWileyMedComm – Biomaterials and Applications2769-643X2025-03-0141n/an/a10.1002/mba2.70003Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and preventionQi Tong0Qiyue Xu1Jie Cai2Yiren Sun3Zhengjie Wang4Yongjun Qian5Department of Cardiovascular Surgery, West China Hospital, Med‐X Center for Materials Sichuan University Chengdu Sichuan ChinaFirst School of Clinical Medicine Mudanjiang Medical University Mudanjiang Heilongjiang ChinaDepartment of Cardiovascular Surgery, West China Hospital, Med‐X Center for Materials Sichuan University Chengdu Sichuan ChinaDepartment of Cardiovascular Surgery, West China Hospital, Med‐X Center for Materials Sichuan University Chengdu Sichuan ChinaDepartment of Cardiovascular Surgery, West China Hospital, Med‐X Center for Materials Sichuan University Chengdu Sichuan ChinaDepartment of Cardiovascular Surgery, West China Hospital, Med‐X Center for Materials Sichuan University Chengdu Sichuan ChinaAbstract At present, cardiovascular infection such as infective endocarditis (IE) has become a major disease with a high mortality rate. The essence of IE is actually the infection associated with biofilm formation, which can occur not only on native heart valves, but also on prosthetic heart valves and cardiovascular implants such as left heart assist devices, vascular grafts, and pacemakers. Biofilms are bacterial aggregates that are composed of a self‐produced extracellular polymeric substance (EPS), which is difficult and challenging for the treatment of cardiovascular infections. Therefore, it is important to explore and develop effective anti‐biofilm methods for the treatment of biofilm‐associated cardiovascular infection. This review provides comprehension of strategies for degrading EPS in biofilm, the application of nanodrug delivery systems for biofilm‐related infections, the strategy for targeting drug resistance genes through gene editing technology and strategy for targeting quorum sensing in biofilm. Furthermore, this review also provides some strategies to optimize the antibacterial properties of cardiovascular implants to prevent biofilm formation. The applications of these strategies will provide novel preventive and therapeutic ways for biofilm‐associated cardiovascular infections.https://doi.org/10.1002/mba2.70003antibacterial modificationbiofilmcardiovascular infectioninfective endocarditisstimuli‐responsive nanodrug delivery systems |
| spellingShingle | Qi Tong Qiyue Xu Jie Cai Yiren Sun Zhengjie Wang Yongjun Qian Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention MedComm – Biomaterials and Applications antibacterial modification biofilm cardiovascular infection infective endocarditis stimuli‐responsive nanodrug delivery systems |
| title | Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention |
| title_full | Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention |
| title_fullStr | Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention |
| title_full_unstemmed | Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention |
| title_short | Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention |
| title_sort | biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention |
| topic | antibacterial modification biofilm cardiovascular infection infective endocarditis stimuli‐responsive nanodrug delivery systems |
| url | https://doi.org/10.1002/mba2.70003 |
| work_keys_str_mv | AT qitong biofilmformationincardiovascularinfectionandbioengineeringapproachesfortreatmentandprevention AT qiyuexu biofilmformationincardiovascularinfectionandbioengineeringapproachesfortreatmentandprevention AT jiecai biofilmformationincardiovascularinfectionandbioengineeringapproachesfortreatmentandprevention AT yirensun biofilmformationincardiovascularinfectionandbioengineeringapproachesfortreatmentandprevention AT zhengjiewang biofilmformationincardiovascularinfectionandbioengineeringapproachesfortreatmentandprevention AT yongjunqian biofilmformationincardiovascularinfectionandbioengineeringapproachesfortreatmentandprevention |