Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine
Abstract This study presents the electrochemical sensing of dopamine (DA) using an electrode of polypyrrole/poly(3,4-ethylenedioxythiophene) (PEDOT-PPy) thin film. Electrochemical analyses of the PEDOT-PPy thin film for DA sensing were conducted through cyclic voltammetry (CV) and differential pulse...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-82355-1 |
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| author | Anandhavelu Sanmugam C. Vanitha Abdulrahman I. Almansour K. Karuppasamy T. Maiyalagan Hyun-Seok Kim Dhanasekaran Vikraman Akram Alfantazi |
| author_facet | Anandhavelu Sanmugam C. Vanitha Abdulrahman I. Almansour K. Karuppasamy T. Maiyalagan Hyun-Seok Kim Dhanasekaran Vikraman Akram Alfantazi |
| author_sort | Anandhavelu Sanmugam |
| collection | DOAJ |
| description | Abstract This study presents the electrochemical sensing of dopamine (DA) using an electrode of polypyrrole/poly(3,4-ethylenedioxythiophene) (PEDOT-PPy) thin film. Electrochemical analyses of the PEDOT-PPy thin film for DA sensing were conducted through cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The CV analysis demonstrated that PEDOT-PPy exhibited superior electrochemical activity towards DA due to its enhanced conductivity as a high-conducting polymer composite. The DPV results indicated a linear concentration level of 5 nM to 200 µM with a minimal limit of sensing of 5 nM using the PEDOT-PPy electrode material. The fabricated sensor explored the sensitivity of 7.27 µA/µM cm2 at the 5 to 1000 nM DA concentration and the dopamine diffusion coefficient of 1.3 × 10–8 cm2/s. Additionally, the PEDOT-PPy electrode material displayed excellent reproducibility, selectivity, and stability. Therefore, the PEDOT-PPy composite electrode material shows excellent potential for outperforming other electrode materials in detecting DA. |
| format | Article |
| id | doaj-art-da25e5c36cd94f858e8f4533cdc65169 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-da25e5c36cd94f858e8f4533cdc651692025-08-20T03:07:41ZengNature PortfolioScientific Reports2045-23222025-03-011511910.1038/s41598-024-82355-1Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamineAnandhavelu Sanmugam0C. Vanitha1Abdulrahman I. Almansour2K. Karuppasamy3T. Maiyalagan4Hyun-Seok Kim5Dhanasekaran Vikraman6Akram Alfantazi7Department of Applied Chemistry, Sri Venkateswara College of EngineeringDepartment of Chemistry, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering CollegeDepartment of Chemistry, College of Science, King Saud UniversityDepartment of Chemical and Petroleum Engineering, Khalifa University of Science and TechnologyDepartment of Chemistry, SRM Institute of Science and TechnologyDivision of Electronics and Electrical Engineering, Dongguk University-SeoulDivision of Electronics and Electrical Engineering, Dongguk University-SeoulDepartment of Chemical and Petroleum Engineering, Khalifa University of Science and TechnologyAbstract This study presents the electrochemical sensing of dopamine (DA) using an electrode of polypyrrole/poly(3,4-ethylenedioxythiophene) (PEDOT-PPy) thin film. Electrochemical analyses of the PEDOT-PPy thin film for DA sensing were conducted through cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The CV analysis demonstrated that PEDOT-PPy exhibited superior electrochemical activity towards DA due to its enhanced conductivity as a high-conducting polymer composite. The DPV results indicated a linear concentration level of 5 nM to 200 µM with a minimal limit of sensing of 5 nM using the PEDOT-PPy electrode material. The fabricated sensor explored the sensitivity of 7.27 µA/µM cm2 at the 5 to 1000 nM DA concentration and the dopamine diffusion coefficient of 1.3 × 10–8 cm2/s. Additionally, the PEDOT-PPy electrode material displayed excellent reproducibility, selectivity, and stability. Therefore, the PEDOT-PPy composite electrode material shows excellent potential for outperforming other electrode materials in detecting DA.https://doi.org/10.1038/s41598-024-82355-1PEDOTSensorPolypyrroleDopamineElectrochemical |
| spellingShingle | Anandhavelu Sanmugam C. Vanitha Abdulrahman I. Almansour K. Karuppasamy T. Maiyalagan Hyun-Seok Kim Dhanasekaran Vikraman Akram Alfantazi Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine Scientific Reports PEDOT Sensor Polypyrrole Dopamine Electrochemical |
| title | Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine |
| title_full | Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine |
| title_fullStr | Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine |
| title_full_unstemmed | Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine |
| title_short | Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine |
| title_sort | unveiling the pedot polypyrrole hybrid electrode for the electrochemical sensing of dopamine |
| topic | PEDOT Sensor Polypyrrole Dopamine Electrochemical |
| url | https://doi.org/10.1038/s41598-024-82355-1 |
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