Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1
To study pathogenetic mechanisms of the development of spinal deformity in neurofibromatosis.Structural components of the spine were presented as specimens obtained after surgical correction of spinal deformity performed in 10 children with III—IV grade scoliosis associated with neurofibromatosis.Et...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2010-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1697 |
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| author | A. M. Zaidman M. V. Mikhailovsky Ye. L. Zaviyalova V. A. Suzdalov M. A. Sadovoy |
| author_facet | A. M. Zaidman M. V. Mikhailovsky Ye. L. Zaviyalova V. A. Suzdalov M. A. Sadovoy |
| author_sort | A. M. Zaidman |
| collection | DOAJ |
| description | To study pathogenetic mechanisms of the development of spinal deformity in neurofibromatosis.Structural components of the spine were presented as specimens obtained after surgical correction of spinal deformity performed in 10 children with III—IV grade scoliosis associated with neurofibromatosis.Etiologic factor of the development of spinal deformity in neurofibromatosis is a mutation of the NF-1 gene in cells of ganglious lamella. Migration of cells carrying mutant gene into one of the sclerotome zones results in oncogene activation and intensive proliferation of chondro-, osteo-, and fibroblasts in the growth plate, intervertebral disc, and vertebral body.Progressive development of the spinal deformity after surgical intervention is accounted both for proliferation of chondro- and fibroblasts in the vertebral body and intervertebral disc and for disturbance of the NF-1 and lumican genes expression. |
| format | Article |
| id | doaj-art-da254d10d0e6498facd4ce1cd159eb3a |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2010-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-da254d10d0e6498facd4ce1cd159eb3a2025-08-20T03:02:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842010-12-0196344010.20538/1682-0363-2010-6-34-401196Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1A. M. Zaidman0M. V. Mikhailovsky1Ye. L. Zaviyalova2V. A. Suzdalov3M. A. Sadovoy4Новосибирский НИИ травматологии и ортопедии РосмедтехнологийНовосибирский НИИ травматологии и ортопедии РосмедтехнологийНовосибирский НИИ травматологии и ортопедии РосмедтехнологийНовосибирский НИИ травматологии и ортопедии РосмедтехнологийНовосибирский НИИ травматологии и ортопедии РосмедтехнологийTo study pathogenetic mechanisms of the development of spinal deformity in neurofibromatosis.Structural components of the spine were presented as specimens obtained after surgical correction of spinal deformity performed in 10 children with III—IV grade scoliosis associated with neurofibromatosis.Etiologic factor of the development of spinal deformity in neurofibromatosis is a mutation of the NF-1 gene in cells of ganglious lamella. Migration of cells carrying mutant gene into one of the sclerotome zones results in oncogene activation and intensive proliferation of chondro-, osteo-, and fibroblasts in the growth plate, intervertebral disc, and vertebral body.Progressive development of the spinal deformity after surgical intervention is accounted both for proliferation of chondro- and fibroblasts in the vertebral body and intervertebral disc and for disturbance of the NF-1 and lumican genes expression.https://bulletin.ssmu.ru/jour/article/view/1697neurofibromatosisgrowth platesclerotomespinal deformitygene expression |
| spellingShingle | A. M. Zaidman M. V. Mikhailovsky Ye. L. Zaviyalova V. A. Suzdalov M. A. Sadovoy Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1 Бюллетень сибирской медицины neurofibromatosis growth plate sclerotome spinal deformity gene expression |
| title | Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1 |
| title_full | Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1 |
| title_fullStr | Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1 |
| title_full_unstemmed | Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1 |
| title_short | Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1 |
| title_sort | structural and functional peculiarities of spine deformity development in neurofibromatosis nf 1 |
| topic | neurofibromatosis growth plate sclerotome spinal deformity gene expression |
| url | https://bulletin.ssmu.ru/jour/article/view/1697 |
| work_keys_str_mv | AT amzaidman structuralandfunctionalpeculiaritiesofspinedeformitydevelopmentinneurofibromatosisnf1 AT mvmikhailovsky structuralandfunctionalpeculiaritiesofspinedeformitydevelopmentinneurofibromatosisnf1 AT yelzaviyalova structuralandfunctionalpeculiaritiesofspinedeformitydevelopmentinneurofibromatosisnf1 AT vasuzdalov structuralandfunctionalpeculiaritiesofspinedeformitydevelopmentinneurofibromatosisnf1 AT masadovoy structuralandfunctionalpeculiaritiesofspinedeformitydevelopmentinneurofibromatosisnf1 |