Synthesis and In Vitro Pharmacological Evaluation of 5,8-Dideaza Analogs of Methotrexate

Synthesis and In Vitro Pharmacological Evaluation of 5,8-Dideaza Analogs of Methotrexate

This study describes the synthesis of a series of dideaza analogs of methotrexate and their preliminary pharmacological and metabolic evaluation. The 5,8-dideazamethotrexate was efficiently obtained in five steps using a new synthetic route. Oxygenated and thiolated analogs of dideazamethotrexate we...

Full description

Saved in:
Bibliographic Details
Main Authors: Marta Abellán-Flos, Charles Skarbek, Dáire J. Gibbons, Estelle Rascol, Ainhoa García, Raphaël Labruère
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
methotrexate
quinazoline
cytotoxicity
DHFR
in vitro metabolism
Online Access:https://www.mdpi.com/1420-3049/30/13/2772
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items