A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba
Euphorbiae Humifusae Herba (EHH) is a globally distributed plant commonly utilized in traditional Chinese medicine (TCM) and health food within China. The dried aerial parts of EHH are well-recognized as health foods for the management of diarrhea and other intestinal diseases. Known for its therape...
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2025-02-01
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| Online Access: | https://www.mdpi.com/1420-3049/30/5/1094 |
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| author | Jian Xiao Hong Gu Jiaqing Zhang Yuqian Xue Yunyi Chen Weizhong Zhu Hong Zhang Boyi Fan Wenli Wang |
| author_facet | Jian Xiao Hong Gu Jiaqing Zhang Yuqian Xue Yunyi Chen Weizhong Zhu Hong Zhang Boyi Fan Wenli Wang |
| author_sort | Jian Xiao |
| collection | DOAJ |
| description | Euphorbiae Humifusae Herba (EHH) is a globally distributed plant commonly utilized in traditional Chinese medicine (TCM) and health food within China. The dried aerial parts of EHH are well-recognized as health foods for the management of diarrhea and other intestinal diseases. Known for its therapeutic effects, such as heat-clearing, detoxification, blood cooling, hemostasis, dampness, elimination, and jaundice relief, EHH has yielded 197 bioactive compounds identified to date, including terpenoids, flavonoids, phenolic acids, tannins, alkaloids, sterols, lactones, coumarins, and other constituents, with flavonoids and terpenoids, highlighting its wide-ranging pharmacological properties and medicinal significance. Despite its popularity in research, limited systematic and comprehensive information has been provided on the EHH. Therefore, we provide an in-depth overview of EHH, covering its botanical characteristics, traditional uses, phytochemical composition, pharmacological properties, and additional applications. Furthermore, it addresses the current challenges and limitations in modern research on EHH, offering critical perspectives to guide future studies in this field. |
| format | Article |
| id | doaj-art-da20b1ead8b044b2b9e4f3d16b16c6b5 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-da20b1ead8b044b2b9e4f3d16b16c6b52025-08-20T02:59:15ZengMDPI AGMolecules1420-30492025-02-01305109410.3390/molecules30051094A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae HerbaJian Xiao0Hong Gu1Jiaqing Zhang2Yuqian Xue3Yunyi Chen4Weizhong Zhu5Hong Zhang6Boyi Fan7Wenli Wang8School of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, ChinaEuphorbiae Humifusae Herba (EHH) is a globally distributed plant commonly utilized in traditional Chinese medicine (TCM) and health food within China. The dried aerial parts of EHH are well-recognized as health foods for the management of diarrhea and other intestinal diseases. Known for its therapeutic effects, such as heat-clearing, detoxification, blood cooling, hemostasis, dampness, elimination, and jaundice relief, EHH has yielded 197 bioactive compounds identified to date, including terpenoids, flavonoids, phenolic acids, tannins, alkaloids, sterols, lactones, coumarins, and other constituents, with flavonoids and terpenoids, highlighting its wide-ranging pharmacological properties and medicinal significance. Despite its popularity in research, limited systematic and comprehensive information has been provided on the EHH. Therefore, we provide an in-depth overview of EHH, covering its botanical characteristics, traditional uses, phytochemical composition, pharmacological properties, and additional applications. Furthermore, it addresses the current challenges and limitations in modern research on EHH, offering critical perspectives to guide future studies in this field.https://www.mdpi.com/1420-3049/30/5/1094Euphorbiae Humifusae Herbapharmacological effectschemical constituentstraditional use |
| spellingShingle | Jian Xiao Hong Gu Jiaqing Zhang Yuqian Xue Yunyi Chen Weizhong Zhu Hong Zhang Boyi Fan Wenli Wang A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba Molecules Euphorbiae Humifusae Herba pharmacological effects chemical constituents traditional use |
| title | A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba |
| title_full | A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba |
| title_fullStr | A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba |
| title_full_unstemmed | A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba |
| title_short | A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba |
| title_sort | comprehensive review of the phytochemistry pharmacology and other applications of euphorbiae humifusae herba |
| topic | Euphorbiae Humifusae Herba pharmacological effects chemical constituents traditional use |
| url | https://www.mdpi.com/1420-3049/30/5/1094 |
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