Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma
Meningiomas are among the most prevalent primary CNS tumors in adults, accounting for nearly 38% of all brain neoplasms. The World Health Organization (WHO) grade assigned to meningiomas guides medical care in patients and is primarily based on tumor histology and malignancy potential. Although ofte...
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| Language: | English |
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Elsevier
2024-03-01
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| Series: | Molecular Therapy: Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950329924000249 |
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| author | Ritanksha Joshi Anuja Sharma Ritu Kulshreshtha |
| author_facet | Ritanksha Joshi Anuja Sharma Ritu Kulshreshtha |
| author_sort | Ritanksha Joshi |
| collection | DOAJ |
| description | Meningiomas are among the most prevalent primary CNS tumors in adults, accounting for nearly 38% of all brain neoplasms. The World Health Organization (WHO) grade assigned to meningiomas guides medical care in patients and is primarily based on tumor histology and malignancy potential. Although often considered benign, meningiomas with complicated histology, limited accessibility for surgical resection, and/or higher malignancy potential (WHO grade 2 and WHO grade 3) are harder to combat, resulting in significant morbidity. With limited treatment options and no systemic therapies, it is imperative to understand meningioma tumorigenesis at the molecular level and identify novel therapeutic targets. The last decade witnessed considerable progress in understanding the noncoding RNA landscape of meningioma, with microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) emerging as molecular entities of interest. This review aims to highlight the commonly dysregulated miRNAs and lncRNAs in meningioma and their correlation with meningioma progression, malignancy, recurrence, and radioresistance. The role of “key” miRNAs as biomarkers and their therapeutic potential has also been reviewed in detail. Furthermore, current and emerging therapeutic modalities for meningioma have been discussed, with emphasis on the need to identify and subsequently employ clinically relevant miRNAs and lncRNAs as novel therapeutic targets and biomarkers. |
| format | Article |
| id | doaj-art-da0f4dc30ce04ee889c0315317324de8 |
| institution | OA Journals |
| issn | 2950-3299 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncology |
| spelling | doaj-art-da0f4dc30ce04ee889c0315317324de82025-08-20T02:32:57ZengElsevierMolecular Therapy: Oncology2950-32992024-03-0132120078210.1016/j.omton.2024.200782Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningiomaRitanksha Joshi0Anuja Sharma1Ritu Kulshreshtha2Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi 110016, IndiaDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi 110016, IndiaDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi 110016, India; Corresponding author: Ritu Kulshreshtha, PhD, Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi 110016, India.Meningiomas are among the most prevalent primary CNS tumors in adults, accounting for nearly 38% of all brain neoplasms. The World Health Organization (WHO) grade assigned to meningiomas guides medical care in patients and is primarily based on tumor histology and malignancy potential. Although often considered benign, meningiomas with complicated histology, limited accessibility for surgical resection, and/or higher malignancy potential (WHO grade 2 and WHO grade 3) are harder to combat, resulting in significant morbidity. With limited treatment options and no systemic therapies, it is imperative to understand meningioma tumorigenesis at the molecular level and identify novel therapeutic targets. The last decade witnessed considerable progress in understanding the noncoding RNA landscape of meningioma, with microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) emerging as molecular entities of interest. This review aims to highlight the commonly dysregulated miRNAs and lncRNAs in meningioma and their correlation with meningioma progression, malignancy, recurrence, and radioresistance. The role of “key” miRNAs as biomarkers and their therapeutic potential has also been reviewed in detail. Furthermore, current and emerging therapeutic modalities for meningioma have been discussed, with emphasis on the need to identify and subsequently employ clinically relevant miRNAs and lncRNAs as novel therapeutic targets and biomarkers.http://www.sciencedirect.com/science/article/pii/S2950329924000249MT: Regular IssuemicroRNAslncRNAsepigeneticsmolecular signaturesmeningioma |
| spellingShingle | Ritanksha Joshi Anuja Sharma Ritu Kulshreshtha Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma Molecular Therapy: Oncology MT: Regular Issue microRNAs lncRNAs epigenetics molecular signatures meningioma |
| title | Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma |
| title_full | Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma |
| title_fullStr | Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma |
| title_full_unstemmed | Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma |
| title_short | Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma |
| title_sort | noncoding rna landscape and their emerging roles as biomarkers and therapeutic targets in meningioma |
| topic | MT: Regular Issue microRNAs lncRNAs epigenetics molecular signatures meningioma |
| url | http://www.sciencedirect.com/science/article/pii/S2950329924000249 |
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