Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by impairment of memory function. The 5XFAD mouse model was analyzed and compared with wild-type (WT) controls for aberrant cortical excitability and hippocampal theta oscillations by using simultaneous video-electro...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/781731 |
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| author | Magdalena Elisabeth Siwek Ralf Müller Christina Henseler Astrid Trog Andreas Lundt Carola Wormuth Karl Broich Dan Ehninger Marco Weiergräber Anna Papazoglou |
| author_facet | Magdalena Elisabeth Siwek Ralf Müller Christina Henseler Astrid Trog Andreas Lundt Carola Wormuth Karl Broich Dan Ehninger Marco Weiergräber Anna Papazoglou |
| author_sort | Magdalena Elisabeth Siwek |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by impairment of memory function. The 5XFAD mouse model was analyzed and compared with wild-type (WT) controls for aberrant cortical excitability and hippocampal theta oscillations by using simultaneous video-electroencephalogram (EEG) monitoring. Seizure staging revealed that 5XFAD mice exhibited cortical hyperexcitability whereas controls did not. In addition, 5XFAD mice displayed a significant increase in hippocampal theta activity from the light to dark phase during nonmotor activity. We also observed a reduction in mean theta frequency in 5XFAD mice compared to controls that was again most prominent during nonmotor activity. Transcriptome analysis of hippocampal probes and subsequent qPCR validation revealed an upregulation of Plcd4 that might be indicative of enhanced muscarinic signalling. Our results suggest that 5XFAD mice exhibit altered cortical excitability, hippocampal dysrhythmicity, and potential changes in muscarinic signaling. |
| format | Article |
| id | doaj-art-da0f240be7d24307bb44fc5a49cd0ef7 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-da0f240be7d24307bb44fc5a49cd0ef72025-08-20T02:21:25ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/781731781731Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s DiseaseMagdalena Elisabeth Siwek0Ralf Müller1Christina Henseler2Astrid Trog3Andreas Lundt4Carola Wormuth5Karl Broich6Dan Ehninger7Marco Weiergräber8Anna Papazoglou9Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, GermanyDepartment of Psychiatry and Psychotherapy, University of Cologne, Faculty of Medicine, Kerpener Street 62, 50937 Cologne, GermanyFederal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, GermanyInstitute of Molecular Psychiatry, University of Bonn, Sigmund-Freud Street 25, 53125 Bonn, GermanyFederal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, GermanyFederal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, GermanyFederal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, GermanyFederal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, GermanyFederal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, GermanyAlzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by impairment of memory function. The 5XFAD mouse model was analyzed and compared with wild-type (WT) controls for aberrant cortical excitability and hippocampal theta oscillations by using simultaneous video-electroencephalogram (EEG) monitoring. Seizure staging revealed that 5XFAD mice exhibited cortical hyperexcitability whereas controls did not. In addition, 5XFAD mice displayed a significant increase in hippocampal theta activity from the light to dark phase during nonmotor activity. We also observed a reduction in mean theta frequency in 5XFAD mice compared to controls that was again most prominent during nonmotor activity. Transcriptome analysis of hippocampal probes and subsequent qPCR validation revealed an upregulation of Plcd4 that might be indicative of enhanced muscarinic signalling. Our results suggest that 5XFAD mice exhibit altered cortical excitability, hippocampal dysrhythmicity, and potential changes in muscarinic signaling.http://dx.doi.org/10.1155/2015/781731 |
| spellingShingle | Magdalena Elisabeth Siwek Ralf Müller Christina Henseler Astrid Trog Andreas Lundt Carola Wormuth Karl Broich Dan Ehninger Marco Weiergräber Anna Papazoglou Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease Neural Plasticity |
| title | Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease |
| title_full | Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease |
| title_fullStr | Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease |
| title_full_unstemmed | Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease |
| title_short | Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease |
| title_sort | altered theta oscillations and aberrant cortical excitatory activity in the 5xfad model of alzheimer s disease |
| url | http://dx.doi.org/10.1155/2015/781731 |
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