Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanisms
The hypoxic plateau environment has a broad impact on human physiological function, and its role in tumor initiation and progression has attracted increasing attention in recent years. This review focuses on the effects of the hypoxic plateau environment on tumor biological behavior through the hypo...
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| Format: | Article |
| Language: | zho |
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Lanzhou University Press
2025-06-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20250213?st=article_issue |
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| author | Guo Jing Shi Jinfen Li Yufan Shi Bing |
| author_facet | Guo Jing Shi Jinfen Li Yufan Shi Bing |
| author_sort | Guo Jing |
| collection | DOAJ |
| description | The hypoxic plateau environment has a broad impact on human physiological function, and its role in tumor initiation and progression has attracted increasing attention in recent years. This review focuses on the effects of the hypoxic plateau environment on tumor biological behavior through the hypoxia-inducible factor (HIF) signaling pathway, oxidative stress response, and changes in the immune microenvironment. Studies have shown that continuous hypoxia can stabilize the expression of HIF-1α, thereby regulating downstream target genes and affecting tumor angiogenesis, energy metabolic reprogramming, and resistance to apoptosis. At the same time, the synergistic effect of strong ultraviolet radiation and hypoxia in the plateau environment can increase the production of reactive oxygen species (ROS), leading to DNA damage and genomic instability. In addition, the hypoxic plateau environment can induce increased myeloid-derived suppressor cell (MDSC) infiltration and upregulation of PD-L1 expression, promoting tumor immune escape. This paper also summarizes tumor prevention strategies for the hypoxic plateau environment, including targeted interventions in the HIF pathway, antioxidant therapy, and immunomodulation, aiming to provide a scientific basis for tumor prevention and treatment in plateau regions. |
| format | Article |
| id | doaj-art-da0d6356c40945b2b27f1b7bb4e11ffb |
| institution | Kabale University |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-da0d6356c40945b2b27f1b7bb4e11ffb2025-08-20T03:28:02ZzhoLanzhou University Press生物医学转化2096-89652025-06-0162868910.12287/j.issn.2096-8965.20250212Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanismsGuo Jing0Shi Jinfen1Li Yufan2Shi Bing37th Medical Center of the General Hospital of the People's Liberation Army, Beijing 100010 , China7th Medical Center of the General Hospital of the People's Liberation Army, Beijing 100010 , China7th Medical Center of the General Hospital of the People's Liberation Army, Beijing 100010 , China7th Medical Center of the General Hospital of the People's Liberation Army, Beijing 100010 , ChinaThe hypoxic plateau environment has a broad impact on human physiological function, and its role in tumor initiation and progression has attracted increasing attention in recent years. This review focuses on the effects of the hypoxic plateau environment on tumor biological behavior through the hypoxia-inducible factor (HIF) signaling pathway, oxidative stress response, and changes in the immune microenvironment. Studies have shown that continuous hypoxia can stabilize the expression of HIF-1α, thereby regulating downstream target genes and affecting tumor angiogenesis, energy metabolic reprogramming, and resistance to apoptosis. At the same time, the synergistic effect of strong ultraviolet radiation and hypoxia in the plateau environment can increase the production of reactive oxygen species (ROS), leading to DNA damage and genomic instability. In addition, the hypoxic plateau environment can induce increased myeloid-derived suppressor cell (MDSC) infiltration and upregulation of PD-L1 expression, promoting tumor immune escape. This paper also summarizes tumor prevention strategies for the hypoxic plateau environment, including targeted interventions in the HIF pathway, antioxidant therapy, and immunomodulation, aiming to provide a scientific basis for tumor prevention and treatment in plateau regions.http://swyxzh.ijournals.cn/swyxzh/article/html/20250213?st=article_issueplateau environmenthypoxiatumor initiationhif signaling pathwayoxidative stresstumor immune microenvironment |
| spellingShingle | Guo Jing Shi Jinfen Li Yufan Shi Bing Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanisms 生物医学转化 plateau environment hypoxia tumor initiation hif signaling pathway oxidative stress tumor immune microenvironment |
| title | Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanisms |
| title_full | Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanisms |
| title_fullStr | Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanisms |
| title_full_unstemmed | Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanisms |
| title_short | Advances in the study of the impact of the hypoxic plateau environment on tumor initiation, progression, and molecular mechanisms |
| title_sort | advances in the study of the impact of the hypoxic plateau environment on tumor initiation progression and molecular mechanisms |
| topic | plateau environment hypoxia tumor initiation hif signaling pathway oxidative stress tumor immune microenvironment |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20250213?st=article_issue |
| work_keys_str_mv | AT guojing advancesinthestudyoftheimpactofthehypoxicplateauenvironmentontumorinitiationprogressionandmolecularmechanisms AT shijinfen advancesinthestudyoftheimpactofthehypoxicplateauenvironmentontumorinitiationprogressionandmolecularmechanisms AT liyufan advancesinthestudyoftheimpactofthehypoxicplateauenvironmentontumorinitiationprogressionandmolecularmechanisms AT shibing advancesinthestudyoftheimpactofthehypoxicplateauenvironmentontumorinitiationprogressionandmolecularmechanisms |