Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia

Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia

Abstract Background Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in clinical trials. Addressing this, B55α, an isoform of protein phosphatase 2A (PP2A), emerges as pivotal in vessel remodeling through activation of hypoxia-indu...

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Main Authors: Adela García-Martín, María E. Prados, Isabel Lastres-Cubillo, Francisco J. Ponce-Diaz, Laura Cerero, Martin Garrido-Rodríguez, Carmen Navarrete, Rafael Pineda, Ana B. Rodríguez, Ignacio Muñoz, Javier Moya, Antonella Medeot, José A. Moreno, Antonio Chacón, José García-Revillo, Eduardo Muñoz
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
Etrinabdione
VCE-004.8
PPA2/B55α
HIF-1α
Sirtuin 1
eNOS
Online Access:https://doi.org/10.1186/s12967-024-05748-w
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