Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review
This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for the relationship between COVID-19 vaccination and Post-COVID-19 Condition (PCC) by timing...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2474772 |
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| _version_ | 1850139877513887744 |
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| author | Abby E. Rudolph Nadine Al Akoury Natalija Bogdanenko Kristen Markus Isabelle Whittle Olivia Wright Hammam Haridy Julia R. Spinardi John M. McLaughlin Moe H. Kyaw |
| author_facet | Abby E. Rudolph Nadine Al Akoury Natalija Bogdanenko Kristen Markus Isabelle Whittle Olivia Wright Hammam Haridy Julia R. Spinardi John M. McLaughlin Moe H. Kyaw |
| author_sort | Abby E. Rudolph |
| collection | DOAJ |
| description | This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for the relationship between COVID-19 vaccination and Post-COVID-19 Condition (PCC) by timing of vaccination relative to infection or PCC-onset. Comparisons of adjusted vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) across study characteristics known to impact PCC burden or VE against other COVID-19 endpoints were possible for 31 studies where vaccination preceded infection. Seventy-seven percent of pre-infection aVE estimates were statistically significant (range: 7%–95%). Statistically significant pre-infection aVE estimates were slightly higher for mRNA (range: 14%–84%) than non-mRNA vaccines (range: 16%–38%) and aVE ranges before and during Omicron overlapped. Our findings suggest that COVID-19 vaccination before SARS-CoV-2 infection reduces the risk of PCC regardless of vaccine type, number of doses received, PCC definition, predominant variant, and severity of acute infections included. |
| format | Article |
| id | doaj-art-da078538901a47419595340c8f8bb01f |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-da078538901a47419595340c8f8bb01f2025-08-20T02:30:04ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2474772Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature reviewAbby E. Rudolph0Nadine Al Akoury1Natalija Bogdanenko2Kristen Markus3Isabelle Whittle4Olivia Wright5Hammam Haridy6Julia R. Spinardi7John M. McLaughlin8Moe H. Kyaw9Pfizer Vaccines, Collegeville, USAPfizer Emerging Markets, Aoukar, LebanonPfizer Vaccines, London, UKAdelphi Values PROVE, Bollington, UKAdelphi Values PROVE, Bollington, UKAdelphi Values PROVE, Bollington, UKPfizer Emerging Markets, Dubai, UAEPfizer Emerging Markets, Sao Paulo, BrazilPfizer Vaccines, Collegeville, USAPfizer Vaccines, Collegeville, USAThis systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for the relationship between COVID-19 vaccination and Post-COVID-19 Condition (PCC) by timing of vaccination relative to infection or PCC-onset. Comparisons of adjusted vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) across study characteristics known to impact PCC burden or VE against other COVID-19 endpoints were possible for 31 studies where vaccination preceded infection. Seventy-seven percent of pre-infection aVE estimates were statistically significant (range: 7%–95%). Statistically significant pre-infection aVE estimates were slightly higher for mRNA (range: 14%–84%) than non-mRNA vaccines (range: 16%–38%) and aVE ranges before and during Omicron overlapped. Our findings suggest that COVID-19 vaccination before SARS-CoV-2 infection reduces the risk of PCC regardless of vaccine type, number of doses received, PCC definition, predominant variant, and severity of acute infections included.https://www.tandfonline.com/doi/10.1080/21645515.2025.2474772Post-COVID conditionsCOVID-19 vaccineSARS-CoV-2long COVIDvaccine effectivenesspost-acute sequelae of SARS-CoV-2 infection |
| spellingShingle | Abby E. Rudolph Nadine Al Akoury Natalija Bogdanenko Kristen Markus Isabelle Whittle Olivia Wright Hammam Haridy Julia R. Spinardi John M. McLaughlin Moe H. Kyaw Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review Human Vaccines & Immunotherapeutics Post-COVID conditions COVID-19 vaccine SARS-CoV-2 long COVID vaccine effectiveness post-acute sequelae of SARS-CoV-2 infection |
| title | Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review |
| title_full | Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review |
| title_fullStr | Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review |
| title_full_unstemmed | Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review |
| title_short | Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review |
| title_sort | factors affecting the impact of covid 19 vaccination on post covid 19 conditions among adults a systematic literature review |
| topic | Post-COVID conditions COVID-19 vaccine SARS-CoV-2 long COVID vaccine effectiveness post-acute sequelae of SARS-CoV-2 infection |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2474772 |
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