Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus
Background: Early detection of malignant pleural effusions (MPE) through routine biochemical tests will go a long way in improving morbidity and mortality of these patients. Aims and Objectives: The current study was aimed to observe the usefulness of cancer ratio (CR) and CR plus to diagnose mal...
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Manipal College of Medical Sciences, Pokhara
2025-02-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4323 |
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| author | Subhankar Saren Animesh Mandal Amit Kumar Das Ranjit Kumar Haldar Sudipta Pandit |
| author_facet | Subhankar Saren Animesh Mandal Amit Kumar Das Ranjit Kumar Haldar Sudipta Pandit |
| author_sort | Subhankar Saren |
| collection | DOAJ |
| description | Background: Early detection of malignant pleural effusions (MPE) through routine biochemical tests will go a long way in improving morbidity and mortality of these patients.
Aims and Objectives: The current study was aimed to observe the usefulness of cancer ratio (CR) and CR plus to diagnose malignant effusions early in disease evolution.
Materials and Methods: The study was a cross-sectional comparative observational study conducted at the indoor and outdoor facility of Respiratory Medicine department of Institute of Post Graduate Medical Education and Research, Kolkata.
Results: Sixty-one patients were included in the study. The overall mean CR in our patients was 40.50±19.83. In MPE, tuberculous pleural effusions (TPE) and “Others”, the mean CR were 49.1839±14.698, 19.2874±16.354, and 30.6107±17.342, respectively. CR with levels above 20 showed very strong statistical association with MPE diagnosis in patients of pleural effusion (P<0.001). The mean CR plus in all patients was found to be 54.58±28.14. According to diagnosis, the means were 65.5645±22.576, 27.3255±24.356, and 43.1169±25.622 in MPE, TPE, and “Others,” respectively. Levels above 30 had shown strong association with MPE diagnosis (P<0.001). Both CR and CR plus had sensitivity of 95.12% (95% CI 80.03–98.64), specificity of 80% (95% CI 60.80–91.16), positive predictive value of 90.69, and negative predictive value of 88.88 in diagnosing MPE.
Conclusion: CR and CR plus which are easily obtained by routine testing can be used for early detection of MPE. |
| format | Article |
| id | doaj-art-da05973fb2f54aa8992b04b4cef26413 |
| institution | Kabale University |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-da05973fb2f54aa8992b04b4cef264132025-02-01T12:23:23ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-02-0116297102https://doi.org/10.71152/ajms.v16i2.4323Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plusSubhankar Saren 0https://orcid.org/0009-0006-9745-1925Animesh Mandal 1https://orcid.org/0009-0007-1170-0933Amit Kumar Das 2https://orcid.org/0000-0002-5782-0419Ranjit Kumar Haldar3https://orcid.org/0009-0009-8796-6468Sudipta Pandit 4https://orcid.org/0009-0003-4414-5586Senior Resident, Department of Respiratory Medicine, M J N Medical College, Coochbehar, West Bengal, India Associate Professor, Department of Respiratory Medicine, SNPH Campus, IPGME and R and SSKM Hospital, Kolkata, West Bengal, India Assistant Professor, Department of Surgery, SNPH Campus, IPGME and R and SSKM Hospital, Kolkata, West Bengal, India Associate Professor, Department of Respiratory Medicine, SNPH Campus, IPGME and R and SSKM Hospital, Kolkata, West Bengal, India Professor, Department of Pulmonary Medicine, SNPH Campus, IPGME and R and SSKM Hospital, Kolkata, West Bengal, India Background: Early detection of malignant pleural effusions (MPE) through routine biochemical tests will go a long way in improving morbidity and mortality of these patients. Aims and Objectives: The current study was aimed to observe the usefulness of cancer ratio (CR) and CR plus to diagnose malignant effusions early in disease evolution. Materials and Methods: The study was a cross-sectional comparative observational study conducted at the indoor and outdoor facility of Respiratory Medicine department of Institute of Post Graduate Medical Education and Research, Kolkata. Results: Sixty-one patients were included in the study. The overall mean CR in our patients was 40.50±19.83. In MPE, tuberculous pleural effusions (TPE) and “Others”, the mean CR were 49.1839±14.698, 19.2874±16.354, and 30.6107±17.342, respectively. CR with levels above 20 showed very strong statistical association with MPE diagnosis in patients of pleural effusion (P<0.001). The mean CR plus in all patients was found to be 54.58±28.14. According to diagnosis, the means were 65.5645±22.576, 27.3255±24.356, and 43.1169±25.622 in MPE, TPE, and “Others,” respectively. Levels above 30 had shown strong association with MPE diagnosis (P<0.001). Both CR and CR plus had sensitivity of 95.12% (95% CI 80.03–98.64), specificity of 80% (95% CI 60.80–91.16), positive predictive value of 90.69, and negative predictive value of 88.88 in diagnosing MPE. Conclusion: CR and CR plus which are easily obtained by routine testing can be used for early detection of MPE.https://ajmsjournal.info/index.php/AJMS/article/view/4323pleural effusion; exudative effusion; malignant pleural effusion; tubercular pleural effusion; pleural fluid biomarkers; cancer ratio; cancer ratio plus |
| spellingShingle | Subhankar Saren Animesh Mandal Amit Kumar Das Ranjit Kumar Haldar Sudipta Pandit Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus Asian Journal of Medical Sciences pleural effusion; exudative effusion; malignant pleural effusion; tubercular pleural effusion; pleural fluid biomarkers; cancer ratio; cancer ratio plus |
| title | Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus |
| title_full | Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus |
| title_fullStr | Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus |
| title_full_unstemmed | Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus |
| title_short | Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus |
| title_sort | identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus |
| topic | pleural effusion; exudative effusion; malignant pleural effusion; tubercular pleural effusion; pleural fluid biomarkers; cancer ratio; cancer ratio plus |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4323 |
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