A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis
Meili Liu,1,2,* Tao You,3,* Shifeng Li,1,* Yan Hao,1,* Zhiyang Wang,1 Fang Huang,1 Jun Wang1 1Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Cardiology, The...
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Dove Medical Press
2025-05-01
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| Series: | Journal of Inflammation Research |
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| author | Liu M You T Li S Hao Y Wang Z Huang F Wang J |
| author_facet | Liu M You T Li S Hao Y Wang Z Huang F Wang J |
| author_sort | Liu M |
| collection | DOAJ |
| description | Meili Liu,1,2,&ast; Tao You,3,&ast; Shifeng Li,1,&ast; Yan Hao,1,&ast; Zhiyang Wang,1 Fang Huang,1 Jun Wang1 1Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Wang; Fang Huang, Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, People’s Republic of China, Email dr_wangjun@suda.edu.cn; blue-virus@163.comObjective: To evaluate the prognosis significance of a newly simplified immune-dysregulation index, interleukin-6-to-lymphocyte ratio (IL-6/LY), in individuals diagnosed with sepsis.Methods: This was a retrospective cohort study enrolling consecutive patients diagnosed with sepsis who qualified the inclusion criteria and were admitted to the intensive care unit of the First Affiliated Hospital of Soochow University between March 2017 and January 2023. Multivariate COX and logistic regression models were used to estimate the association between IL-6/LY and 28-day in-hospital mortality or multiple organ dysfunction syndrome (MODS). Restricted cubic splines and survival analysis were used to show a nonlinear correlation between IL-6/LY and mortality. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the prognostic value of IL-6/LY. was performed using the Kaplan‒Meier method.Results: The study encompassed 301 participants, categorized into two groups—those with low IL-6/LY and high IL-6/LY—determined by the cutoff value of 326.04. On multivariate analyses, a high IL-6/LY was independently associated with 28-day in-hospital mortality (hazard ratio [HR]: 8.01, 95% confidence interval [CI] 4.67– 13.74, P < 0.001) and MODS (odds ratio [OR] 3.44, 95% CI 1.85‒6.38, P < 0.001). The area under the curve of IL-6/LY for predicting death and MODS were 0.893 (95% CI, 0.855– 0.931) and 0.743 (95% CI, 0.688– 0.798), respectively. The Kaplan‒Meier analysis showed a significantly higher risk of mortality in the high IL-6/LY group (≥ 326.04) (log-rank P < 0.001).Conclusion: The IL-6/LY is significantly associated with the risk of 28-day in-hospital mortality and MODS in patients with sepsis, making it a potential prognostic marker for risk stratification, which enables early identification of high-risk patients, timely interventions, and personalized treatment strategies to optimize patient outcomes.Keywords: sepsis, interleukin-6, 28-day in-hospital mortality, MODS, prognosis |
| format | Article |
| id | doaj-art-d9fbf3d055644875a26060ce8e934aea |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
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| series | Journal of Inflammation Research |
| spelling | doaj-art-d9fbf3d055644875a26060ce8e934aea2025-08-20T03:32:36ZengDove Medical PressJournal of Inflammation Research1178-70312025-05-01Volume 18Issue 169456958103384A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with SepsisLiu M0You T1Li S2Hao Y3Wang Z4Huang F5Wang J6Department of CardiologyDepartment of HematologyDepartment of Intensive Care Medicinecritical careCritical Care MedicineDepartment of Intensive Care MedicineDepartment of Intensive Care MedicineMeili Liu,1,2,&ast; Tao You,3,&ast; Shifeng Li,1,&ast; Yan Hao,1,&ast; Zhiyang Wang,1 Fang Huang,1 Jun Wang1 1Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Wang; Fang Huang, Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, People’s Republic of China, Email dr_wangjun@suda.edu.cn; blue-virus@163.comObjective: To evaluate the prognosis significance of a newly simplified immune-dysregulation index, interleukin-6-to-lymphocyte ratio (IL-6/LY), in individuals diagnosed with sepsis.Methods: This was a retrospective cohort study enrolling consecutive patients diagnosed with sepsis who qualified the inclusion criteria and were admitted to the intensive care unit of the First Affiliated Hospital of Soochow University between March 2017 and January 2023. Multivariate COX and logistic regression models were used to estimate the association between IL-6/LY and 28-day in-hospital mortality or multiple organ dysfunction syndrome (MODS). Restricted cubic splines and survival analysis were used to show a nonlinear correlation between IL-6/LY and mortality. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the prognostic value of IL-6/LY. was performed using the Kaplan‒Meier method.Results: The study encompassed 301 participants, categorized into two groups—those with low IL-6/LY and high IL-6/LY—determined by the cutoff value of 326.04. On multivariate analyses, a high IL-6/LY was independently associated with 28-day in-hospital mortality (hazard ratio [HR]: 8.01, 95% confidence interval [CI] 4.67– 13.74, P < 0.001) and MODS (odds ratio [OR] 3.44, 95% CI 1.85‒6.38, P < 0.001). The area under the curve of IL-6/LY for predicting death and MODS were 0.893 (95% CI, 0.855– 0.931) and 0.743 (95% CI, 0.688– 0.798), respectively. The Kaplan‒Meier analysis showed a significantly higher risk of mortality in the high IL-6/LY group (≥ 326.04) (log-rank P < 0.001).Conclusion: The IL-6/LY is significantly associated with the risk of 28-day in-hospital mortality and MODS in patients with sepsis, making it a potential prognostic marker for risk stratification, which enables early identification of high-risk patients, timely interventions, and personalized treatment strategies to optimize patient outcomes.Keywords: sepsis, interleukin-6, 28-day in-hospital mortality, MODS, prognosishttps://www.dovepress.com/a-simplified-immune-dysregulation-index-il-6ly-as-a-robust-predictor-o-peer-reviewed-fulltext-article-JIRSepsisInterleukin-628-day in-hospital mortalityMODSprognosis |
| spellingShingle | Liu M You T Li S Hao Y Wang Z Huang F Wang J A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis Journal of Inflammation Research Sepsis Interleukin-6 28-day in-hospital mortality MODS prognosis |
| title | A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis |
| title_full | A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis |
| title_fullStr | A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis |
| title_full_unstemmed | A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis |
| title_short | A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis |
| title_sort | simplified immune dysregulation index il 6 ly as a robust predictor of 28 day in hospital mortality and mods in patients with sepsis |
| topic | Sepsis Interleukin-6 28-day in-hospital mortality MODS prognosis |
| url | https://www.dovepress.com/a-simplified-immune-dysregulation-index-il-6ly-as-a-robust-predictor-o-peer-reviewed-fulltext-article-JIR |
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