Polysorbates degrading enzymes in biotherapeutics – a current status and future perspectives

Polysorbates degrading enzymes in biotherapeutics – a current status and future perspectives

Polysorbates, in particular polysorbate (PS) 20 and 80, are the most commonly used surfactants for stabilising biotherapeutics produced by biotechnological processes. PSs are derived from ethoxylated sorbitan (a derivative of sorbitol) esterified with fatty acids of varying chain length and degree o...

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Bibliographic Details
Main Authors: Marius Nicolaus Felix, Thomas Waerner, Daniel Lakatos, Bernd Reisinger, Simon Fischer, Patrick Garidel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
biotherapeutics
polysorbate
tween
enzymatic degradation
HCP
mass spectrometry
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1490276/full
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