Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC

Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC

Abstract Background Dysregulation of alternative splicing plays a pivotal role in tumorigenesis and metastasis in triple-negative breast cancer (TNBC). Serine/arginine-rich (SR) proteins, essential components of the spliceosome, undergo phosphorylation by Cdc2-like kinase (CLK). Here we explored the...

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Bibliographic Details
Main Authors: Nasi Liu, Jurjun J. S. van der Velde, Sherien Ramdjielal, Esmee Koedoot, Nila K. van Overbeek, Daisy Batenburg, Alfred C. O. Vertegaal, Bob van de Water, Sylvia E. Le Dévédec
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
Alternative splicing
Cdc2-like kinase
Serine/arginine-rich proteins
Online Access:https://doi.org/10.1186/s13058-025-02091-w
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