Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients
Background. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus. Methods. 19 ESRD patients under hemodialysis with sev...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/363901 |
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| author | Mansor Shakiba Hoshang Sanadgol Hamid Reza Azmoude Mohamad Ali Mashhadi Hassan Sharifi |
| author_facet | Mansor Shakiba Hoshang Sanadgol Hamid Reza Azmoude Mohamad Ali Mashhadi Hassan Sharifi |
| author_sort | Mansor Shakiba |
| collection | DOAJ |
| description | Background. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus.
Methods. 19 ESRD patients under hemodialysis with severe chronic pruritus were randomly selected to participate in this before-after clinical trial. Before and after starting treatment with sertraline, a detailed pruritus history was obtained and pruritus graded by the 30-item inventory of pruritus that patients based on priorities grade allocated to 3 classes. Subjects were treated with sertraline 50 mg oral daily for four months, with monthly assessments of pruritus symptoms.
Results. Before treatment with sertraline, the grade of pruritus in 9 (47.4%) patients was moderate and severe in 10 (52.6%) patients. After treatment, grade of pruritus in 11 (57.8%) patients was weak, 6 (31.5%) have moderate and only 2 (10.7%) patients have severe pruritus. Of 10 patients with severe pruritus, 5 (50%) patients experiencing weak pruritus, and 4 (40%) patients have moderate pruritus after treatment. Based on Wilcoxon signed-rank test, the difference between the grade of pruritus before and after treatment with sertraline was significant (P=0.001).
Conclusions. Although no definitive recommendation can be made regarding treatment of uremic pruritus, we found an increased antipruritic effect of sertraline in ESRD patients. |
| format | Article |
| id | doaj-art-d9fa9e4726084c2880f2e852d3446bc1 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-d9fa9e4726084c2880f2e852d3446bc12025-08-20T03:24:25ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/363901363901Effect of Sertraline on Uremic Pruritus Improvement in ESRD PatientsMansor Shakiba0Hoshang Sanadgol1Hamid Reza Azmoude2Mohamad Ali Mashhadi3Hassan Sharifi4Department of Psychiatry, Zahedan University of Medical Sciences, Zahedan 98167-43463, IranDepartment of Nephrology, Zahedan University of Medical Sciences, Zahedan 98167-43463, IranDepartment of Internal Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43463, IranHematology/Oncology Ward, Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43463, IranMedical Surgical Nursing, Departments of Nursing, Iranshahr School of Nursing and Midwifery, Zahedan University of Medical Sciences, Iranshahr 9914786838, IranBackground. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus. Methods. 19 ESRD patients under hemodialysis with severe chronic pruritus were randomly selected to participate in this before-after clinical trial. Before and after starting treatment with sertraline, a detailed pruritus history was obtained and pruritus graded by the 30-item inventory of pruritus that patients based on priorities grade allocated to 3 classes. Subjects were treated with sertraline 50 mg oral daily for four months, with monthly assessments of pruritus symptoms. Results. Before treatment with sertraline, the grade of pruritus in 9 (47.4%) patients was moderate and severe in 10 (52.6%) patients. After treatment, grade of pruritus in 11 (57.8%) patients was weak, 6 (31.5%) have moderate and only 2 (10.7%) patients have severe pruritus. Of 10 patients with severe pruritus, 5 (50%) patients experiencing weak pruritus, and 4 (40%) patients have moderate pruritus after treatment. Based on Wilcoxon signed-rank test, the difference between the grade of pruritus before and after treatment with sertraline was significant (P=0.001). Conclusions. Although no definitive recommendation can be made regarding treatment of uremic pruritus, we found an increased antipruritic effect of sertraline in ESRD patients.http://dx.doi.org/10.1155/2012/363901 |
| spellingShingle | Mansor Shakiba Hoshang Sanadgol Hamid Reza Azmoude Mohamad Ali Mashhadi Hassan Sharifi Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients International Journal of Nephrology |
| title | Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients |
| title_full | Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients |
| title_fullStr | Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients |
| title_full_unstemmed | Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients |
| title_short | Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients |
| title_sort | effect of sertraline on uremic pruritus improvement in esrd patients |
| url | http://dx.doi.org/10.1155/2012/363901 |
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