Small molecule UCM05 inhibits HSV-2 infection via targeting viral glycoproteins and fatty acid synthase with potentiating antiviral immunity

Small molecule UCM05 inhibits HSV-2 infection via targeting viral glycoproteins and fatty acid synthase with potentiating antiviral immunity

Abstract Herpes simplex virus type 2 (HSV-2) is a highly prevalent human pathogen worldwide that not only causes genital herpes but is also associated with severe health complications, such as neonatal infections and increased susceptibility to HIV. Currently, due to the lack of an effective HSV-2 v...

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Bibliographic Details
Main Authors: Songshan Li, Minghan Li, Yantong Cai, Jun Xian, Rongrong Zhu, Chan Yang, Xin Zhang, Shuya Ren, Aijiao Yu, Shuwen Liu, Bin Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Virology Journal
Subjects:
UCM05
HSV-2
Entry inhibition
Fatty acid synthesis
Immune enhancement
Co-infections
Online Access:https://doi.org/10.1186/s12985-025-02867-8
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