In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-R
Cancer belongs to a group of diseases characterized by uncontrolled cell growth. The search for new effective treatments for cancer has led to the discovery of different molecules from plants, bacteria, and fungi with pharmacological use. Plant endophytic fungi are large producers of metabolites wit...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/12/11/2310 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846152889439879168 |
|---|---|
| author | Diana Laura Clark-Pérez César Iván Romo-Sáenz Jesica María Ramírez-Villalobos Patricia Tamez-Guerra Diana Caballero-Hernández Ana Laura Delgado-Miranda Andrés García Joel Horacio Elizondo-Luevano Cristina Rodríguez-Padilla Ricardo Gomez-Flores |
| author_facet | Diana Laura Clark-Pérez César Iván Romo-Sáenz Jesica María Ramírez-Villalobos Patricia Tamez-Guerra Diana Caballero-Hernández Ana Laura Delgado-Miranda Andrés García Joel Horacio Elizondo-Luevano Cristina Rodríguez-Padilla Ricardo Gomez-Flores |
| author_sort | Diana Laura Clark-Pérez |
| collection | DOAJ |
| description | Cancer belongs to a group of diseases characterized by uncontrolled cell growth. The search for new effective treatments for cancer has led to the discovery of different molecules from plants, bacteria, and fungi with pharmacological use. Plant endophytic fungi are large producers of metabolites with antitumor properties. We aimed to evaluate the in vitro and in vivo antitumor potential of extracts from <i>Lophocereus marginatus</i> endophytic fungi. We obtained ethyl acetate and hexane extracts from the <i>L. marginatus</i> endophytes <i>Metarhizium anisopliae</i> and <i>Aspergillus versicolor</i> and evaluated their antitumor activity against murine L5178Y-R lymphoma cells and human peripheral blood mononuclear cells, using the 3-(4,5-dimethylthiazol-2-yl)-2-diphenyltetrazolium bromide reduction colorimetric technique. <i>M. anisopliae</i> and <i>A. versicolor</i> ethyl acetate extracts showed IC<sub>50</sub> values of 9.168 ± 1.21 μg/mL and 13.51 ± 1.62, respectively, and selectivity indices > 30. We also observed that the maximum tolerated dose (100 mg/kg) of ethyl acetate extracts and the vehicle in BALB/c mice did not cause hepatotoxicity. In addition, we evaluated the effects of ethyl acetate extracts on survival and tumor volume in the L5178Y-R lymphoma tumor model. An increase in survival (17 d) was observed in mice treated with <i>A. versicolor</i> extract. Furthermore, it did not increase tumor volume during 10 d, as compared with the control groups without treatment, vehicle, and <i>M. anisopliae</i> extract, which had a maximum survival of 10 d. <i>A. versicolor</i> ethyl acetate extract showed in vitro and in vivo antitumor activity against lymphoma L5178Y-R, increasing mice survival. |
| format | Article |
| id | doaj-art-d9f6eaf8362c41df9a4b002befe28bf6 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-d9f6eaf8362c41df9a4b002befe28bf62024-11-26T18:14:54ZengMDPI AGMicroorganisms2076-26072024-11-011211231010.3390/microorganisms12112310In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-RDiana Laura Clark-Pérez0César Iván Romo-Sáenz1Jesica María Ramírez-Villalobos2Patricia Tamez-Guerra3Diana Caballero-Hernández4Ana Laura Delgado-Miranda5Andrés García6Joel Horacio Elizondo-Luevano7Cristina Rodríguez-Padilla8Ricardo Gomez-Flores9Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma del Estado de Morelos Centro de Investigación en Biotecnología, Laboratorio de Biotecnología Ambiental, Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoUniversidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, San Nicolás de los Garza 66455, Nuevo León, MexicoCancer belongs to a group of diseases characterized by uncontrolled cell growth. The search for new effective treatments for cancer has led to the discovery of different molecules from plants, bacteria, and fungi with pharmacological use. Plant endophytic fungi are large producers of metabolites with antitumor properties. We aimed to evaluate the in vitro and in vivo antitumor potential of extracts from <i>Lophocereus marginatus</i> endophytic fungi. We obtained ethyl acetate and hexane extracts from the <i>L. marginatus</i> endophytes <i>Metarhizium anisopliae</i> and <i>Aspergillus versicolor</i> and evaluated their antitumor activity against murine L5178Y-R lymphoma cells and human peripheral blood mononuclear cells, using the 3-(4,5-dimethylthiazol-2-yl)-2-diphenyltetrazolium bromide reduction colorimetric technique. <i>M. anisopliae</i> and <i>A. versicolor</i> ethyl acetate extracts showed IC<sub>50</sub> values of 9.168 ± 1.21 μg/mL and 13.51 ± 1.62, respectively, and selectivity indices > 30. We also observed that the maximum tolerated dose (100 mg/kg) of ethyl acetate extracts and the vehicle in BALB/c mice did not cause hepatotoxicity. In addition, we evaluated the effects of ethyl acetate extracts on survival and tumor volume in the L5178Y-R lymphoma tumor model. An increase in survival (17 d) was observed in mice treated with <i>A. versicolor</i> extract. Furthermore, it did not increase tumor volume during 10 d, as compared with the control groups without treatment, vehicle, and <i>M. anisopliae</i> extract, which had a maximum survival of 10 d. <i>A. versicolor</i> ethyl acetate extract showed in vitro and in vivo antitumor activity against lymphoma L5178Y-R, increasing mice survival.https://www.mdpi.com/2076-2607/12/11/2310anticancermedicinal plantsextractslymphomamice survival |
| spellingShingle | Diana Laura Clark-Pérez César Iván Romo-Sáenz Jesica María Ramírez-Villalobos Patricia Tamez-Guerra Diana Caballero-Hernández Ana Laura Delgado-Miranda Andrés García Joel Horacio Elizondo-Luevano Cristina Rodríguez-Padilla Ricardo Gomez-Flores In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-R Microorganisms anticancer medicinal plants extracts lymphoma mice survival |
| title | In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-R |
| title_full | In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-R |
| title_fullStr | In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-R |
| title_full_unstemmed | In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-R |
| title_short | In Vitro and In Vivo Antitumor Activity of <i>Lophocereus marginatus</i> (DC.) S. Arias & Terrazas Endophytic <i>Aspergillus versicolor</i> and <i>Metarhizium anisopliae</i> Extracts Against the Murine Lymphoma L5178Y-R |
| title_sort | in vitro and in vivo antitumor activity of i lophocereus marginatus i dc s arias terrazas endophytic i aspergillus versicolor i and i metarhizium anisopliae i extracts against the murine lymphoma l5178y r |
| topic | anticancer medicinal plants extracts lymphoma mice survival |
| url | https://www.mdpi.com/2076-2607/12/11/2310 |
| work_keys_str_mv | AT dianalauraclarkperez invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT cesarivanromosaenz invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT jesicamariaramirezvillalobos invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT patriciatamezguerra invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT dianacaballerohernandez invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT analauradelgadomiranda invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT andresgarcia invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT joelhoracioelizondoluevano invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT cristinarodriguezpadilla invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr AT ricardogomezflores invitroandinvivoantitumoractivityofilophocereusmarginatusidcsariasterrazasendophyticiaspergillusversicoloriandimetarhiziumanisopliaeiextractsagainstthemurinelymphomal5178yr |