Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization
Graphene oxide (GO) and mesoporous silica nanoparticle (MSN) have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties. The design of GO–MSN nanocomposite offers a large surface area, adjustable pore size, biocompatibility, and low cytotoxicity. The...
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Tsinghua University Press
2024-09-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.26599/NBE.2024.9290076 |
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| author | Ketan B. Patil Jayvadan K. Patel Hardik H. Goswami Arjun S. Chaudhari |
| author_facet | Ketan B. Patil Jayvadan K. Patel Hardik H. Goswami Arjun S. Chaudhari |
| author_sort | Ketan B. Patil |
| collection | DOAJ |
| description | Graphene oxide (GO) and mesoporous silica nanoparticle (MSN) have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties. The design of GO–MSN nanocomposite offers a large surface area, adjustable pore size, biocompatibility, and low cytotoxicity. The application of acyclovir (ACV) (BCS: III) is suffering from poor permeability, low bioavailability, etc. Hence, the use of GO–MSN nanocomposite for the delivery of ACV may overcome the limitations of ACV. Therefore, the present work aims to design the lipid-coated ACV-loaded GO–MSN (LC-ACV-GO–MSN) nanocomposites. In brief, the design of experiments (DoE, 32 response surface methodology) approach was preferred for the development of GO–MSN nanocomposite. The loading of ACV in nanocomposite was done passive loading whereas the coating of lipids was done using a modified thin film hydration technique. At last, different spectral characterizations were performed. The output demonstrated that the entrapment efficiency of ACV-MSN and ACV-GO–MSN was 51.13% and 71.86%, respectively. Afterward, the designed LC-ACV-GO–MSN and ACV-GO–MSN nanocomposite shows 93.40% and 80.74% in vitro drug release, respectively. In conclusion, the design of LC-ACV-GO–MSN nanocomposite using optimized GO–MSN followed lipid coating offers the modified release. Therefore, in the future, LC-ACV-GO–MSN nanocomposite can be used for the delivery of ACV and other drug molecules with a high payload and enhanced release profile. We hope the current proof of concept may provide advantages over existing methods and emphasize the significance of protocells in cargo delivery systems. |
| format | Article |
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| institution | OA Journals |
| issn | 2097-3837 2150-5578 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
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| series | Nano Biomedicine and Engineering |
| spelling | doaj-art-d9f17c87e874466a948b4a5bf088ed332025-08-20T02:13:56ZengTsinghua University PressNano Biomedicine and Engineering2097-38372150-55782024-09-0116344345910.26599/NBE.2024.9290076Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro CharacterizationKetan B. Patil0Jayvadan K. Patel1Hardik H. Goswami2Arjun S. Chaudhari3Nootan Pharmacy College, Sankalchand Patel University, Visnagar 384315, Gujarat, IndiaAavis Pharmaceuticals, Hoschton, GA 30548, USABiostatistics and Research Decision Sciences and Health Economics and Decision Sciences, Merck & Co, North Wales, PA, USAAavis Pharmaceuticals, Hoschton, GA 30548, USAGraphene oxide (GO) and mesoporous silica nanoparticle (MSN) have been documented as advanced nanocarriers for drug delivery due to their unique and versatile properties. The design of GO–MSN nanocomposite offers a large surface area, adjustable pore size, biocompatibility, and low cytotoxicity. The application of acyclovir (ACV) (BCS: III) is suffering from poor permeability, low bioavailability, etc. Hence, the use of GO–MSN nanocomposite for the delivery of ACV may overcome the limitations of ACV. Therefore, the present work aims to design the lipid-coated ACV-loaded GO–MSN (LC-ACV-GO–MSN) nanocomposites. In brief, the design of experiments (DoE, 32 response surface methodology) approach was preferred for the development of GO–MSN nanocomposite. The loading of ACV in nanocomposite was done passive loading whereas the coating of lipids was done using a modified thin film hydration technique. At last, different spectral characterizations were performed. The output demonstrated that the entrapment efficiency of ACV-MSN and ACV-GO–MSN was 51.13% and 71.86%, respectively. Afterward, the designed LC-ACV-GO–MSN and ACV-GO–MSN nanocomposite shows 93.40% and 80.74% in vitro drug release, respectively. In conclusion, the design of LC-ACV-GO–MSN nanocomposite using optimized GO–MSN followed lipid coating offers the modified release. Therefore, in the future, LC-ACV-GO–MSN nanocomposite can be used for the delivery of ACV and other drug molecules with a high payload and enhanced release profile. We hope the current proof of concept may provide advantages over existing methods and emphasize the significance of protocells in cargo delivery systems.https://www.sciopen.com/article/10.26599/NBE.2024.9290076graphene oxide (go)–mesoporous silica nanoparticle (msn)acyclovir (acv)protocelldrug delivery system (dds)design of experiments (doe) |
| spellingShingle | Ketan B. Patil Jayvadan K. Patel Hardik H. Goswami Arjun S. Chaudhari Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization Nano Biomedicine and Engineering graphene oxide (go)–mesoporous silica nanoparticle (msn) acyclovir (acv) protocell drug delivery system (dds) design of experiments (doe) |
| title | Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization |
| title_full | Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization |
| title_fullStr | Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization |
| title_full_unstemmed | Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization |
| title_short | Design of Surface Modified Acyclovir-loaded Graphene Oxide–Mesoporous Silica Nanocomposite: Optimization and In Vitro Characterization |
| title_sort | design of surface modified acyclovir loaded graphene oxide mesoporous silica nanocomposite optimization and in vitro characterization |
| topic | graphene oxide (go)–mesoporous silica nanoparticle (msn) acyclovir (acv) protocell drug delivery system (dds) design of experiments (doe) |
| url | https://www.sciopen.com/article/10.26599/NBE.2024.9290076 |
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