Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review

Cutaneous ageing has attracted widespread interest in recent decades, and the global market for non-invasive rejuvenation procedures is expanding, with hyaluronic acid (HA)-based fillers playing a significant role. The conversion of HA into a filler product is a complex and multidimensional process...

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Main Authors: Vincent Wong, Martina Manni
Format: Article
Language:English
Published: BioExcel Publishing Ltd 2025-08-01
Series:Drugs in Context
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Online Access:https://www.drugsincontext.com/properties-and-potentialities-of-hyaluronic-acid-and-excellent-tridimensional-reticulation-as-a-filling-agent-a-review/
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author Vincent Wong
Martina Manni
author_facet Vincent Wong
Martina Manni
author_sort Vincent Wong
collection DOAJ
description Cutaneous ageing has attracted widespread interest in recent decades, and the global market for non-invasive rejuvenation procedures is expanding, with hyaluronic acid (HA)-based fillers playing a significant role. The conversion of HA into a filler product is a complex and multidimensional process that involves several key stages. Each HA-based filler has rheological features that vary depending on the manufacturing process and lead to particular behaviours when injected into specific anatomical locations. Clinicians must be equipped to select dermal fillers with properties that align with the intended aesthetic outcome. Several key factors influence this decision, including the anatomical characteristics of the injection site, the consistency and thickness of the surrounding tissues, the firmness of retaining structures, the degree of mimetic muscle activity and external mechanical forces on the face as well as the specific anatomical plane targeted for injection. These variables differ not only by facial region but also between individuals, highlighting the importance of thorough patient evaluation. HA fillers are widely recognized for their safety and biocompatibility, with most adverse effects being localized and transient, typically occurring at or near the injection site. Our literature review covers the capabilities and potentials of HA and eXcellent Tridimensional Reticulation (XTR™) in the treatment of skin ageing.
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spelling doaj-art-d9f005a6e8ce47b4ae2367448f32cae42025-08-20T03:02:48ZengBioExcel Publishing LtdDrugs in Context1740-43982025-08-011411010.7573/dic.2025-1-1Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a reviewVincent WongMartina ManniCutaneous ageing has attracted widespread interest in recent decades, and the global market for non-invasive rejuvenation procedures is expanding, with hyaluronic acid (HA)-based fillers playing a significant role. The conversion of HA into a filler product is a complex and multidimensional process that involves several key stages. Each HA-based filler has rheological features that vary depending on the manufacturing process and lead to particular behaviours when injected into specific anatomical locations. Clinicians must be equipped to select dermal fillers with properties that align with the intended aesthetic outcome. Several key factors influence this decision, including the anatomical characteristics of the injection site, the consistency and thickness of the surrounding tissues, the firmness of retaining structures, the degree of mimetic muscle activity and external mechanical forces on the face as well as the specific anatomical plane targeted for injection. These variables differ not only by facial region but also between individuals, highlighting the importance of thorough patient evaluation. HA fillers are widely recognized for their safety and biocompatibility, with most adverse effects being localized and transient, typically occurring at or near the injection site. Our literature review covers the capabilities and potentials of HA and eXcellent Tridimensional Reticulation (XTR™) in the treatment of skin ageing.https://www.drugsincontext.com/properties-and-potentialities-of-hyaluronic-acid-and-excellent-tridimensional-reticulation-as-a-filling-agent-a-review/aesthetic outcomesfacial rejuvenationfillerhyaluronic acidxtr™ technology
spellingShingle Vincent Wong
Martina Manni
Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review
Drugs in Context
aesthetic outcomes
facial rejuvenation
filler
hyaluronic acid
xtr™ technology
title Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review
title_full Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review
title_fullStr Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review
title_full_unstemmed Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review
title_short Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review
title_sort properties and potentialities of hyaluronic acid and excellent tridimensional reticulation as a filling agent a review
topic aesthetic outcomes
facial rejuvenation
filler
hyaluronic acid
xtr™ technology
url https://www.drugsincontext.com/properties-and-potentialities-of-hyaluronic-acid-and-excellent-tridimensional-reticulation-as-a-filling-agent-a-review/
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