Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies
[Objective] To retrospectively analyse the serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies, and to provide reference for safe, timely, and effective blood transfusion. [Methods] Two cases of patients with RhCcEe and Kidd blood type who experienced allo...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-04-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.014&lang=en |
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| _version_ | 1850144545310769152 |
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| author | ZENG Qunjuan YANG Hecai LI Xi QIAN Yulin JIAO Xin |
| author_facet | ZENG Qunjuan YANG Hecai LI Xi QIAN Yulin JIAO Xin |
| author_sort | ZENG Qunjuan |
| collection | DOAJ |
| description | [Objective] To retrospectively analyse the serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies, and to provide reference for safe, timely, and effective blood transfusion. [Methods] Two cases of patients with RhCcEe and Kidd blood type who experienced allogeneic transfusion at Dazhou Central Hospital were selected. A series of immunohematological tests were performed, including ABO, RhDCcEe and Kidd blood typing, unexpected antibody screening and identification, crossmatching, direct antiglobulin test, acid elution test, and capillary centrifugation to separate the patient's own red blood cells from donated red blood cells. [Results] Unexpected antibody screening, antibody identification, and direct antiglobulin test were positive in both patients. Case 1 had anti-Jkb in the plasma, but no specific antibodies were found in the eluate. Case 2 had anti-c and E in the plasma, and anti-E was detected in the eluate. High-speed capillary centrifugation revealed corresponding antigen-positive erythrocytes at the distal end of the blood samples of both patients. [Conclusion] Case 1 received Kidd allogeneic red blood cells, and case 2 received RhCcEe allogeneic red blood cells, and both patients developed the corresponding unexpected antibodies, which led to the occurrence of immune haemolytic blood transfusion reaction. |
| format | Article |
| id | doaj-art-d9efb70875494dfa8e5ec6ef37384a8f |
| institution | OA Journals |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-d9efb70875494dfa8e5ec6ef37384a8f2025-08-20T02:28:19ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-04-0138455155610.13303/j.cjbt.issn.1004-549x.2025.04.0141004-549X(2025)4-0551-05Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodiesZENG Qunjuan0YANG Hecai1LI Xi2QIAN Yulin3JIAO Xin4Dazhou Central Hospital, Dazhou 635000, ChinaHenan Red Cross Blood Center, Zhengzhou 450000, ChinaDazhou Central Hospital, Dazhou 635000, ChinaDazhou Central Hospital, Dazhou 635000, ChinaDazhou Central Hospital, Dazhou 635000, China[Objective] To retrospectively analyse the serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies, and to provide reference for safe, timely, and effective blood transfusion. [Methods] Two cases of patients with RhCcEe and Kidd blood type who experienced allogeneic transfusion at Dazhou Central Hospital were selected. A series of immunohematological tests were performed, including ABO, RhDCcEe and Kidd blood typing, unexpected antibody screening and identification, crossmatching, direct antiglobulin test, acid elution test, and capillary centrifugation to separate the patient's own red blood cells from donated red blood cells. [Results] Unexpected antibody screening, antibody identification, and direct antiglobulin test were positive in both patients. Case 1 had anti-Jkb in the plasma, but no specific antibodies were found in the eluate. Case 2 had anti-c and E in the plasma, and anti-E was detected in the eluate. High-speed capillary centrifugation revealed corresponding antigen-positive erythrocytes at the distal end of the blood samples of both patients. [Conclusion] Case 1 received Kidd allogeneic red blood cells, and case 2 received RhCcEe allogeneic red blood cells, and both patients developed the corresponding unexpected antibodies, which led to the occurrence of immune haemolytic blood transfusion reaction.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.014&lang=enallogeneic transfusionunexpected antibodiesmixed fieldhaemolytic transfusion reaction |
| spellingShingle | ZENG Qunjuan YANG Hecai LI Xi QIAN Yulin JIAO Xin Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies Zhongguo shuxue zazhi allogeneic transfusion unexpected antibodies mixed field haemolytic transfusion reaction |
| title | Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies |
| title_full | Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies |
| title_fullStr | Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies |
| title_full_unstemmed | Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies |
| title_short | Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies |
| title_sort | serological characteristics of hemolytic transfusion reactions caused by rh and kidd antibodies |
| topic | allogeneic transfusion unexpected antibodies mixed field haemolytic transfusion reaction |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.014&lang=en |
| work_keys_str_mv | AT zengqunjuan serologicalcharacteristicsofhemolytictransfusionreactionscausedbyrhandkiddantibodies AT yanghecai serologicalcharacteristicsofhemolytictransfusionreactionscausedbyrhandkiddantibodies AT lixi serologicalcharacteristicsofhemolytictransfusionreactionscausedbyrhandkiddantibodies AT qianyulin serologicalcharacteristicsofhemolytictransfusionreactionscausedbyrhandkiddantibodies AT jiaoxin serologicalcharacteristicsofhemolytictransfusionreactionscausedbyrhandkiddantibodies |