Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers
The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), c...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2912671 |
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| author | Marconi Rego Barros Talita Helena Araújo de Oliveira Cristiane Moutinho Lagos de Melo Aldo Venuti Antonio Carlos de Freitas |
| author_facet | Marconi Rego Barros Talita Helena Araújo de Oliveira Cristiane Moutinho Lagos de Melo Aldo Venuti Antonio Carlos de Freitas |
| author_sort | Marconi Rego Barros |
| collection | DOAJ |
| description | The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells. Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools. |
| format | Article |
| id | doaj-art-d9ea9a0104cd4b928a5726ffc2cacd10 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d9ea9a0104cd4b928a5726ffc2cacd102025-08-20T02:21:13ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/29126712912671Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated CancersMarconi Rego Barros0Talita Helena Araújo de Oliveira1Cristiane Moutinho Lagos de Melo2Aldo Venuti3Antonio Carlos de Freitas4Laboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Av. Prof Moraes Rego, 1235 Cidade Universitária 50670-901 Recife, PE, BrazilLaboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Av. Prof Moraes Rego, 1235 Cidade Universitária 50670-901 Recife, PE, BrazilLaboratory of Immunological and Antitumor Analysis (LAIA), Department of Antibiotics, Center of Biological Sciences, Federal University of Pernambuco, Av. Prof Artur de Sá, s/n, Cidade Universitária 50740-525 Recife, PE, BrazilTumor Immunology and Immunotherapy Unit, Department of Research, Advanced Diagnostic and Technological Innovation, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Roma, ItalyLaboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Av. Prof Moraes Rego, 1235 Cidade Universitária 50670-901 Recife, PE, BrazilThe modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells. Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools.http://dx.doi.org/10.1155/2018/2912671 |
| spellingShingle | Marconi Rego Barros Talita Helena Araújo de Oliveira Cristiane Moutinho Lagos de Melo Aldo Venuti Antonio Carlos de Freitas Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers Journal of Immunology Research |
| title | Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers |
| title_full | Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers |
| title_fullStr | Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers |
| title_full_unstemmed | Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers |
| title_short | Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers |
| title_sort | viral modulation of tlrs and cytokines and the related immunotherapies for hpv associated cancers |
| url | http://dx.doi.org/10.1155/2018/2912671 |
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