Microglia: A Potential Drug Target for Traumatic Axonal Injury
Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important fact...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/5554824 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849472826757611520 |
|---|---|
| author | Xin Huang Wendong You Yuanrun Zhu Kangli Xu Xiaofeng Yang Liang Wen |
| author_facet | Xin Huang Wendong You Yuanrun Zhu Kangli Xu Xiaofeng Yang Liang Wen |
| author_sort | Xin Huang |
| collection | DOAJ |
| description | Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI. |
| format | Article |
| id | doaj-art-d9e8bb7c0369465a8cc72a68c4dddc10 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d9e8bb7c0369465a8cc72a68c4dddc102025-08-20T03:24:24ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/55548245554824Microglia: A Potential Drug Target for Traumatic Axonal InjuryXin Huang0Wendong You1Yuanrun Zhu2Kangli Xu3Xiaofeng Yang4Liang Wen5Department of Neurosurgery, First Affiliated Hospital, Zhejiang University School of Medicine, ChinaEmergency and Trauma Center, First Affiliated Hospital, Zhejiang University School of Medicine, ChinaEmergency and Trauma Center, First Affiliated Hospital, Zhejiang University School of Medicine, ChinaEmergency and Trauma Center, First Affiliated Hospital, Zhejiang University School of Medicine, ChinaDepartment of Neurosurgery, First Affiliated Hospital, Zhejiang University School of Medicine, ChinaDepartment of Neurosurgery, First Affiliated Hospital, Zhejiang University School of Medicine, ChinaTraumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI.http://dx.doi.org/10.1155/2021/5554824 |
| spellingShingle | Xin Huang Wendong You Yuanrun Zhu Kangli Xu Xiaofeng Yang Liang Wen Microglia: A Potential Drug Target for Traumatic Axonal Injury Neural Plasticity |
| title | Microglia: A Potential Drug Target for Traumatic Axonal Injury |
| title_full | Microglia: A Potential Drug Target for Traumatic Axonal Injury |
| title_fullStr | Microglia: A Potential Drug Target for Traumatic Axonal Injury |
| title_full_unstemmed | Microglia: A Potential Drug Target for Traumatic Axonal Injury |
| title_short | Microglia: A Potential Drug Target for Traumatic Axonal Injury |
| title_sort | microglia a potential drug target for traumatic axonal injury |
| url | http://dx.doi.org/10.1155/2021/5554824 |
| work_keys_str_mv | AT xinhuang microgliaapotentialdrugtargetfortraumaticaxonalinjury AT wendongyou microgliaapotentialdrugtargetfortraumaticaxonalinjury AT yuanrunzhu microgliaapotentialdrugtargetfortraumaticaxonalinjury AT kanglixu microgliaapotentialdrugtargetfortraumaticaxonalinjury AT xiaofengyang microgliaapotentialdrugtargetfortraumaticaxonalinjury AT liangwen microgliaapotentialdrugtargetfortraumaticaxonalinjury |