IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and initiates atopic dermatitis inflammation

IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and initiates atopic dermatitis inflammation

Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disorder caused by immune dysregulation that involves the release of various pro-inflammatory cytokines. Patients with AD frequently exhibit basophil infiltration in the affected skin. Although the role of the NLRP3 inflammasome in innat...

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Main Authors: Yoshitaka Gunji, Takayoshi Matsumura, Tadayoshi Karasawa, Takanori Komada, Chintogtokh Baatarjav, Satoko Komori, Hidetoshi Aizawa, Yoshiko Mizushina, Hidetoshi Tsuda, Kensuke Miyake, Takashi Maruyama, Tsukasa Ohmori, Hajime Karasuyama, Masafumi Takahashi
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02630-6
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