EFFECT OF TOXOCARA CANIS SECOND STAGE LARVAE ON THE HOST IMMUNE SYSTEM
We have studied functional alteration of immunocytes in mice following inoculation of Toxocara canis second stage larvae. Results indicated depression of lymphocyte blastogenesis in response to concanavalin-A, phytohemagglutinin and allogeneic non B-cells; however, B-cell polyclonal activation was n...
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| Language: | English |
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University of Tehran
1990-06-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31318_cb4fdba99aa849a234a5a54676a1ceb9.pdf |
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| collection | DOAJ |
| description | We have studied functional alteration of immunocytes in mice following
inoculation of Toxocara canis second stage larvae. Results indicated depression
of lymphocyte blastogenesis in response to concanavalin-A,
phytohemagglutinin and allogeneic non B-cells; however, B-cell polyclonal
activation was not affected as indicated by the production of total IgG.
In contrast, frequency of antibody secreting cells was reduced. Similarly,
interleukin-1 and interleukin-2 production were not affected by Toxocara
canis infection. Furthermore, spleen cells of infected mice synthesized
more prostaglandin E than uninfected animals. This data suggests that
Toxocara canis infection induces suppression of both cell mediated and
humoral immunity; perhaps due to an increase of prostoglandin E2 production. |
| format | Article |
| id | doaj-art-d9e48b8d444448bc9708f37a509785b3 |
| institution | DOAJ |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 1990-06-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-d9e48b8d444448bc9708f37a509785b32025-08-20T03:08:46ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69141990-06-011331318EFFECT OF TOXOCARA CANIS SECOND STAGE LARVAE ON THE HOST IMMUNE SYSTEMWe have studied functional alteration of immunocytes in mice following inoculation of Toxocara canis second stage larvae. Results indicated depression of lymphocyte blastogenesis in response to concanavalin-A, phytohemagglutinin and allogeneic non B-cells; however, B-cell polyclonal activation was not affected as indicated by the production of total IgG. In contrast, frequency of antibody secreting cells was reduced. Similarly, interleukin-1 and interleukin-2 production were not affected by Toxocara canis infection. Furthermore, spleen cells of infected mice synthesized more prostaglandin E than uninfected animals. This data suggests that Toxocara canis infection induces suppression of both cell mediated and humoral immunity; perhaps due to an increase of prostoglandin E2 production.https://jsciences.ut.ac.ir/article_31318_cb4fdba99aa849a234a5a54676a1ceb9.pdf |
| spellingShingle | EFFECT OF TOXOCARA CANIS SECOND STAGE
LARVAE ON THE HOST IMMUNE SYSTEM Journal of Sciences, Islamic Republic of Iran |
| title | EFFECT OF TOXOCARA CANIS SECOND STAGE
LARVAE ON THE HOST IMMUNE SYSTEM |
| title_full | EFFECT OF TOXOCARA CANIS SECOND STAGE
LARVAE ON THE HOST IMMUNE SYSTEM |
| title_fullStr | EFFECT OF TOXOCARA CANIS SECOND STAGE
LARVAE ON THE HOST IMMUNE SYSTEM |
| title_full_unstemmed | EFFECT OF TOXOCARA CANIS SECOND STAGE
LARVAE ON THE HOST IMMUNE SYSTEM |
| title_short | EFFECT OF TOXOCARA CANIS SECOND STAGE
LARVAE ON THE HOST IMMUNE SYSTEM |
| title_sort | effect of toxocara canis second stage larvae on the host immune system |
| url | https://jsciences.ut.ac.ir/article_31318_cb4fdba99aa849a234a5a54676a1ceb9.pdf |