DNA Methylation Changes during In Vitro Propagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability?

Mesenchymal stem cells (MSCs) hold great promise for the treatment of numerous diseases. A major problem for MSC therapeutic use is represented by the very low amount of MSCs which can be isolated from different tissues; thus ex vivo expansion is indispensable. Long-term culture, however, is associa...

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Bibliographic Details
Main Authors: Angela Bentivegna, Mariarosaria Miloso, Gabriele Riva, Dana Foudah, Valentina Butta, Leda Dalprà, Giovanni Tredici
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2013/192425
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