Comparative effectiveness of original and generic losartan in patients with arterial hypertension
Aim. To compare clinical effectiveness and tolerability of original (Cozaar®) and generic (Lozap®) losartan in high and very high-risk patients with Stage I-II arterial hypertension (AH). Material and methods. This blind, randomized (envelope method), parallel study included 40 patients, 20 subjects...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2007-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1390 |
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| author | S. V. Nedogoda T. A. Chalyabi V. V. Tsoma U. A. Brel G. V. Mazina |
| author_facet | S. V. Nedogoda T. A. Chalyabi V. V. Tsoma U. A. Brel G. V. Mazina |
| author_sort | S. V. Nedogoda |
| collection | DOAJ |
| description | Aim. To compare clinical effectiveness and tolerability of original (Cozaar®) and generic (Lozap®) losartan in high and very high-risk patients with Stage I-II arterial hypertension (AH). Material and methods. This blind, randomized (envelope method), parallel study included 40 patients, 20 subjects in each group. After 14-day wash-out period, the participants were administered Cozaar® or Lozap® (50 mg/d; 1 tablet in the morning) for 3 months. Results. Cozaar® and Lozap® reduced systolic blood pressure (SBP) by 11,6% and 12,0% (р<0,05), respectively, diastolic BP (DBP) – by 8,3% and 8,2% (р<0,05), respectively (office measurement data). According to 24-hour BP monitoring data, T/P for SBP was 67,1% and 66,3% in Cozaar® and Lozap® groups, respectively (p<0,05). Both agents similarly reduced left ventricular posterior wall thickness, carotid-femoral and carotid-radial pulse wave rates – by 16,6%, 9,9%, 12,8% vs 16,6%, 10,1%, and 12,2%, respectively. Conclusion. Original and generic losartan medications were similar by antihypertensive activity and effects on surrogate end-points. |
| format | Article |
| id | doaj-art-d9df7160c50047788b246194dda17892 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2007-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-d9df7160c50047788b246194dda178922025-08-20T02:59:54Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252007-12-016610141100Comparative effectiveness of original and generic losartan in patients with arterial hypertensionS. V. Nedogoda0T. A. Chalyabi1V. V. Tsoma2U. A. Brel3G. V. Mazina4Volgograd State Medical University, VolgogradVolgograd State Medical University, VolgogradVolgograd State Medical University, VolgogradVolgograd State Medical University, VolgogradVolgograd State Medical University, VolgogradAim. To compare clinical effectiveness and tolerability of original (Cozaar®) and generic (Lozap®) losartan in high and very high-risk patients with Stage I-II arterial hypertension (AH). Material and methods. This blind, randomized (envelope method), parallel study included 40 patients, 20 subjects in each group. After 14-day wash-out period, the participants were administered Cozaar® or Lozap® (50 mg/d; 1 tablet in the morning) for 3 months. Results. Cozaar® and Lozap® reduced systolic blood pressure (SBP) by 11,6% and 12,0% (р<0,05), respectively, diastolic BP (DBP) – by 8,3% and 8,2% (р<0,05), respectively (office measurement data). According to 24-hour BP monitoring data, T/P for SBP was 67,1% and 66,3% in Cozaar® and Lozap® groups, respectively (p<0,05). Both agents similarly reduced left ventricular posterior wall thickness, carotid-femoral and carotid-radial pulse wave rates – by 16,6%, 9,9%, 12,8% vs 16,6%, 10,1%, and 12,2%, respectively. Conclusion. Original and generic losartan medications were similar by antihypertensive activity and effects on surrogate end-points.https://cardiovascular.elpub.ru/jour/article/view/1390arterial hypertensionlosartangenerics |
| spellingShingle | S. V. Nedogoda T. A. Chalyabi V. V. Tsoma U. A. Brel G. V. Mazina Comparative effectiveness of original and generic losartan in patients with arterial hypertension Кардиоваскулярная терапия и профилактика arterial hypertension losartan generics |
| title | Comparative effectiveness of original and generic losartan in patients with arterial hypertension |
| title_full | Comparative effectiveness of original and generic losartan in patients with arterial hypertension |
| title_fullStr | Comparative effectiveness of original and generic losartan in patients with arterial hypertension |
| title_full_unstemmed | Comparative effectiveness of original and generic losartan in patients with arterial hypertension |
| title_short | Comparative effectiveness of original and generic losartan in patients with arterial hypertension |
| title_sort | comparative effectiveness of original and generic losartan in patients with arterial hypertension |
| topic | arterial hypertension losartan generics |
| url | https://cardiovascular.elpub.ru/jour/article/view/1390 |
| work_keys_str_mv | AT svnedogoda comparativeeffectivenessoforiginalandgenericlosartaninpatientswitharterialhypertension AT tachalyabi comparativeeffectivenessoforiginalandgenericlosartaninpatientswitharterialhypertension AT vvtsoma comparativeeffectivenessoforiginalandgenericlosartaninpatientswitharterialhypertension AT uabrel comparativeeffectivenessoforiginalandgenericlosartaninpatientswitharterialhypertension AT gvmazina comparativeeffectivenessoforiginalandgenericlosartaninpatientswitharterialhypertension |