MicroRNAs as Biomarkers in Thyroid Carcinoma
Optimal management of patients with thyroid cancer requires the use of sensitive and specific biomarkers. For early diagnosis and effective follow-up, the currently available cytological and serum biomarkers, thyroglobulin and calcitonin, present severe limitations. Research on microRNA expression i...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2017/6496570 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850167428987748352 |
|---|---|
| author | Marilena Celano Francesca Rosignolo Valentina Maggisano Valeria Pecce Michelangelo Iannone Diego Russo Stefania Bulotta |
| author_facet | Marilena Celano Francesca Rosignolo Valentina Maggisano Valeria Pecce Michelangelo Iannone Diego Russo Stefania Bulotta |
| author_sort | Marilena Celano |
| collection | DOAJ |
| description | Optimal management of patients with thyroid cancer requires the use of sensitive and specific biomarkers. For early diagnosis and effective follow-up, the currently available cytological and serum biomarkers, thyroglobulin and calcitonin, present severe limitations. Research on microRNA expression in thyroid tumors is providing new insights for the development of novel biomarkers that can be used to diagnose thyroid cancer and optimize its management. In this review, we will examine some of the methods commonly used to detect and quantify microRNA in biospecimens from patients with thyroid tumor, as well as the potential applications of these techniques for developing microRNA-based biomarkers for the diagnosis and prognostic evaluation of thyroid cancers. |
| format | Article |
| id | doaj-art-d9d5181f2db7476fa52e694d6c7e1c77 |
| institution | OA Journals |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-d9d5181f2db7476fa52e694d6c7e1c772025-08-20T02:21:13ZengWileyInternational Journal of Genomics2314-436X2314-43782017-01-01201710.1155/2017/64965706496570MicroRNAs as Biomarkers in Thyroid CarcinomaMarilena Celano0Francesca Rosignolo1Valentina Maggisano2Valeria Pecce3Michelangelo Iannone4Diego Russo5Stefania Bulotta6Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyCNR, Institute of Neurological Sciences, Section of Pharmacology, Roccelletta di Borgia, 88021 Borgia, ItalyDepartment of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyOptimal management of patients with thyroid cancer requires the use of sensitive and specific biomarkers. For early diagnosis and effective follow-up, the currently available cytological and serum biomarkers, thyroglobulin and calcitonin, present severe limitations. Research on microRNA expression in thyroid tumors is providing new insights for the development of novel biomarkers that can be used to diagnose thyroid cancer and optimize its management. In this review, we will examine some of the methods commonly used to detect and quantify microRNA in biospecimens from patients with thyroid tumor, as well as the potential applications of these techniques for developing microRNA-based biomarkers for the diagnosis and prognostic evaluation of thyroid cancers.http://dx.doi.org/10.1155/2017/6496570 |
| spellingShingle | Marilena Celano Francesca Rosignolo Valentina Maggisano Valeria Pecce Michelangelo Iannone Diego Russo Stefania Bulotta MicroRNAs as Biomarkers in Thyroid Carcinoma International Journal of Genomics |
| title | MicroRNAs as Biomarkers in Thyroid Carcinoma |
| title_full | MicroRNAs as Biomarkers in Thyroid Carcinoma |
| title_fullStr | MicroRNAs as Biomarkers in Thyroid Carcinoma |
| title_full_unstemmed | MicroRNAs as Biomarkers in Thyroid Carcinoma |
| title_short | MicroRNAs as Biomarkers in Thyroid Carcinoma |
| title_sort | micrornas as biomarkers in thyroid carcinoma |
| url | http://dx.doi.org/10.1155/2017/6496570 |
| work_keys_str_mv | AT marilenacelano micrornasasbiomarkersinthyroidcarcinoma AT francescarosignolo micrornasasbiomarkersinthyroidcarcinoma AT valentinamaggisano micrornasasbiomarkersinthyroidcarcinoma AT valeriapecce micrornasasbiomarkersinthyroidcarcinoma AT michelangeloiannone micrornasasbiomarkersinthyroidcarcinoma AT diegorusso micrornasasbiomarkersinthyroidcarcinoma AT stefaniabulotta micrornasasbiomarkersinthyroidcarcinoma |