Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study
Background/Aims Small bowel bleeding (SBB) is the main indication for videocapsule endoscopy (VCE); the diagnostic yield (DY) could be influenced by antithrombotic therapies. We explored the effects of these therapies on SBB. Methods Consecutive patients from two centers (Milan, Italy and Sheffield,...
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Korean Society of Gastrointestinal Endoscopy
2025-01-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://www.e-ce.org/upload/pdf/ce-2024-073.pdf |
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| author | Lucia Scaramella Stefania Chetcuti Zammit Reena Sidhu Maurizio Vecchi Gian Eugenio Tontini Nicoletta Nandi Matilde Topa Luca Elli |
| author_facet | Lucia Scaramella Stefania Chetcuti Zammit Reena Sidhu Maurizio Vecchi Gian Eugenio Tontini Nicoletta Nandi Matilde Topa Luca Elli |
| author_sort | Lucia Scaramella |
| collection | DOAJ |
| description | Background/Aims Small bowel bleeding (SBB) is the main indication for videocapsule endoscopy (VCE); the diagnostic yield (DY) could be influenced by antithrombotic therapies. We explored the effects of these therapies on SBB. Methods Consecutive patients from two centers (Milan, Italy and Sheffield, UK) who underwent VCE between March 2001 and July 2020 were considered. Demographic data, clinical parameters, drug therapy, and technical characteristics of the procedure were collected. VCE findings and DY were evaluated. Results In total, 957 patients (1,052 VCEs) underwent VCE for SBB (DY 50.6%, no retention); 27 patients (27 VCEs) received direct oral anticoagulants, 87 (88 VCEs) received other anticoagulants, 115 (135 VCEs) received antiplatelet therapy, 198 (218 VCEs) received monotherapy, and 31 (32 VCEs) received combined therapy. There were no differences in the completion rate, findings, and DYs between each subgroup or between monotherapy and combined therapy. The overt bleeding rate was similar in all groups, even when comparing antithrombotic users versus those not on therapy (p=0.59) or monotherapy versus combined therapy (p=0.34). Conclusions VCE is safe and has a high clinical impact on SBB. Antithrombotic therapies did not affect DY or overt bleeding rate and, consequently, can be considered safe in terms of SBB risk. |
| format | Article |
| id | doaj-art-d9d4f8f2600b4f06b9b3832e60c630eb |
| institution | Kabale University |
| issn | 2234-2400 2234-2443 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj-art-d9d4f8f2600b4f06b9b3832e60c630eb2025-02-03T08:08:03ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432025-01-0158110211110.5946/ce.2024.0737936Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective studyLucia Scaramella0Stefania Chetcuti Zammit1Reena Sidhu2Maurizio Vecchi3Gian Eugenio Tontini4Nicoletta Nandi5Matilde Topa6Luca Elli7 Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy Gastroenterology Department, Mater Dei Hospital, Malta, Italy Academic Dept of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground/Aims Small bowel bleeding (SBB) is the main indication for videocapsule endoscopy (VCE); the diagnostic yield (DY) could be influenced by antithrombotic therapies. We explored the effects of these therapies on SBB. Methods Consecutive patients from two centers (Milan, Italy and Sheffield, UK) who underwent VCE between March 2001 and July 2020 were considered. Demographic data, clinical parameters, drug therapy, and technical characteristics of the procedure were collected. VCE findings and DY were evaluated. Results In total, 957 patients (1,052 VCEs) underwent VCE for SBB (DY 50.6%, no retention); 27 patients (27 VCEs) received direct oral anticoagulants, 87 (88 VCEs) received other anticoagulants, 115 (135 VCEs) received antiplatelet therapy, 198 (218 VCEs) received monotherapy, and 31 (32 VCEs) received combined therapy. There were no differences in the completion rate, findings, and DYs between each subgroup or between monotherapy and combined therapy. The overt bleeding rate was similar in all groups, even when comparing antithrombotic users versus those not on therapy (p=0.59) or monotherapy versus combined therapy (p=0.34). Conclusions VCE is safe and has a high clinical impact on SBB. Antithrombotic therapies did not affect DY or overt bleeding rate and, consequently, can be considered safe in terms of SBB risk.http://www.e-ce.org/upload/pdf/ce-2024-073.pdfanticoagulantscapsule endoscopygastrointestinal hemorrhageplatelet aggregation inhibitors |
| spellingShingle | Lucia Scaramella Stefania Chetcuti Zammit Reena Sidhu Maurizio Vecchi Gian Eugenio Tontini Nicoletta Nandi Matilde Topa Luca Elli Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study Clinical Endoscopy anticoagulants capsule endoscopy gastrointestinal hemorrhage platelet aggregation inhibitors |
| title | Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study |
| title_full | Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study |
| title_fullStr | Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study |
| title_full_unstemmed | Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study |
| title_short | Effect of antithrombotic therapies on small bowel bleeding: an European multicenter retrospective study |
| title_sort | effect of antithrombotic therapies on small bowel bleeding an european multicenter retrospective study |
| topic | anticoagulants capsule endoscopy gastrointestinal hemorrhage platelet aggregation inhibitors |
| url | http://www.e-ce.org/upload/pdf/ce-2024-073.pdf |
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