Clinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factors
Background/Aim. Mechanical thrombectomy (MT) is an endovascular treatment that involves the extraction of thrombotic masses in the first hours of acute ischemic stroke (AIS) from the large blood vessels of the head and/or neck. The aim of the study was to determine the role of predictors (time and v...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2024-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400063M.pdf |
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| author | Mileusnić Valentina Grkić Irena Zečević Aleksandra |
| author_facet | Mileusnić Valentina Grkić Irena Zečević Aleksandra |
| author_sort | Mileusnić Valentina |
| collection | DOAJ |
| description | Background/Aim. Mechanical thrombectomy (MT) is an endovascular treatment that involves the extraction of thrombotic masses in the first hours of acute ischemic stroke (AIS) from the large blood vessels of the head and/or neck. The aim of the study was to determine the role of predictors (time and vascular risk factors) of the clinical outcome of patients with AIS monitored by the National Institute of Health Stroke Scale (NIHSS). Methods. The study included 134 patients diagnosed with occlusion of a blood vessel of the head and/or neck with a clinical picture of AIS who met the criteria for MT and in whom, upon admission to the hospital, existing vascular risk factors were observed. In relation to the time parameter from the onset of the clinical picture of AIS to the start of MT, the patients were divided into two groups. The first, the examined group, consisted of 85 (63.4%) patients in whom recanalization was initiated within the first four hours from the onset of symptoms, and the second, the control group, consisted of 49 (36.6%) patients in whom recanalization was initiated after the fourth hour. The results were monitored by the change of the NIHSS score at the time of discharge of the patient, on the 30th and 90th day, in relation to the NIHSS score on admission. Results. There was no statistically significant difference between the groups except for the variables endovascular treatment (EVT) and previous vascular event [cardiovascular disease (CVD)] (p < 0.05). A statistically significant correlation was found between improvement and the time when EVT was performed in relation to the onset of complaints (χ2(1) = 4.756; p < 0.05). A statistically significant correlation was also found between improvement and CVD (χ2(1) = 4.756; p < 0.05). Conclusion. The results of our study support MT as a promising stand-alone therapy for AIS. Clinical outcome monitored by the NIHSS after MT in relation to time and cerebrovascular risk factors shows that patients in whom EVT was performed in the first four hours have an improvement more often than patients in whom E VT was performed four hrs after the onset of symptoms. Likewise, patients without CVD were more likely to show improvement than patients with CVD. |
| format | Article |
| id | doaj-art-d9d4ec69cfd14a32995fc89e36048f36 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-d9d4ec69cfd14a32995fc89e36048f362025-08-20T02:03:47ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202024-01-01811168168710.2298/VSP240305063M0042-84502400063MClinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factorsMileusnić Valentina0Grkić Irena1Zečević Aleksandra2University Hospital Medical Center Bežanijska Kosa, Belgrade, SerbiaSpecial Hospital for Cerebrovascular Diseases “Sveti Sava”, Belgrade, SerbiaSpecial Hospital for Cerebrovascular Diseases “Sveti Sava”, Belgrade, SerbiaBackground/Aim. Mechanical thrombectomy (MT) is an endovascular treatment that involves the extraction of thrombotic masses in the first hours of acute ischemic stroke (AIS) from the large blood vessels of the head and/or neck. The aim of the study was to determine the role of predictors (time and vascular risk factors) of the clinical outcome of patients with AIS monitored by the National Institute of Health Stroke Scale (NIHSS). Methods. The study included 134 patients diagnosed with occlusion of a blood vessel of the head and/or neck with a clinical picture of AIS who met the criteria for MT and in whom, upon admission to the hospital, existing vascular risk factors were observed. In relation to the time parameter from the onset of the clinical picture of AIS to the start of MT, the patients were divided into two groups. The first, the examined group, consisted of 85 (63.4%) patients in whom recanalization was initiated within the first four hours from the onset of symptoms, and the second, the control group, consisted of 49 (36.6%) patients in whom recanalization was initiated after the fourth hour. The results were monitored by the change of the NIHSS score at the time of discharge of the patient, on the 30th and 90th day, in relation to the NIHSS score on admission. Results. There was no statistically significant difference between the groups except for the variables endovascular treatment (EVT) and previous vascular event [cardiovascular disease (CVD)] (p < 0.05). A statistically significant correlation was found between improvement and the time when EVT was performed in relation to the onset of complaints (χ2(1) = 4.756; p < 0.05). A statistically significant correlation was also found between improvement and CVD (χ2(1) = 4.756; p < 0.05). Conclusion. The results of our study support MT as a promising stand-alone therapy for AIS. Clinical outcome monitored by the NIHSS after MT in relation to time and cerebrovascular risk factors shows that patients in whom EVT was performed in the first four hours have an improvement more often than patients in whom E VT was performed four hrs after the onset of symptoms. Likewise, patients without CVD were more likely to show improvement than patients with CVD.https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400063M.pdfendovascular proceduresischemic strokerisk factorstime-to-treatmenttreatment outcome |
| spellingShingle | Mileusnić Valentina Grkić Irena Zečević Aleksandra Clinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factors Vojnosanitetski Pregled endovascular procedures ischemic stroke risk factors time-to-treatment treatment outcome |
| title | Clinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factors |
| title_full | Clinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factors |
| title_fullStr | Clinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factors |
| title_full_unstemmed | Clinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factors |
| title_short | Clinical outcome in patients monitored by the NIHSS after mechanical thrombectomy in relation to time and cerebrovascular risk factors |
| title_sort | clinical outcome in patients monitored by the nihss after mechanical thrombectomy in relation to time and cerebrovascular risk factors |
| topic | endovascular procedures ischemic stroke risk factors time-to-treatment treatment outcome |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400063M.pdf |
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