Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study
BackgroundRecent studies have shown an association between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD), but the association in a population of pregnant women remains unclear.ObjectivesOur study aimed to examine the association between AIP and NAFLD in pregnant Kore...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1511952/full |
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| author | Rong Shuai Yuxing He Dongqian Yang Yingying Zhang Li Zhang |
| author_facet | Rong Shuai Yuxing He Dongqian Yang Yingying Zhang Li Zhang |
| author_sort | Rong Shuai |
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| description | BackgroundRecent studies have shown an association between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD), but the association in a population of pregnant women remains unclear.ObjectivesOur study aimed to examine the association between AIP and NAFLD in pregnant Korean women.MethodsOur study used publicly available data from Korea, which recruited singleton pregnant women between November 2014 and September 2016 who were at 10–14 weeks of gestation. The presence of NAFLD was diagnosed by liver ultrasound. AIP was calculated as log10 (TG/HDL). Participants were grouped according to AIP tertile: T1 (< 0.16, n = 195), T2 (0.16–0.32, n = 195), and T3 (>0.32, n = 196). Logistic regression models were used to estimate the relationship between AIP and NAFLD. Subgroup and sensitivity analyses were conducted to explore the stability of this relationship. Restricted cubic spline (RCS) curve fitting was employed to investigate potential non-linear associations.ResultsAfter excluding data on missing variables, 586 singleton pregnant women were finally included. The subjects included in the study had an average AIP of 0.22 (0.11, 0.37), and NAFLD occurred in 110 (18.8%) pregnant women. We observed a positive linear association between AIP and NAFLD (OR = 1.33, 95% CI: 1.19–1.48), which persisted after adjusting for potential confounders (OR = 1.2, 95% CI: 1.06–1.37). When AIP was used as a categorical variable, after adjusting for covariates, the NAFLD risk was significantly higher in the highest tertile of AIP than in the lowest group (OR = 2.02, 95% CI: 1.11–3.68). Their correlations were stable across subgroups and sensitivity analyses.ConclusionIn this secondary analysis of a prospective cohort study of pregnant Korean women, AIP was found to be positively associated with NAFLD. These outcomes might be used to screen for NAFLD in pregnant women. |
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| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-d9c117dc804f46338b3732ee0412affe2025-01-31T05:10:14ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15119521511952Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort studyRong Shuai0Yuxing He1Dongqian Yang2Yingying Zhang3Li Zhang4Department of Laboratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde, ChinaDepartment of Laboratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde, ChinaDepartment of Laboratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde, ChinaDepartment of Laboratory Medicine, Affiliated Wuxi Fifth Hospital of Jiangnan University, Wuxi, ChinaDepartment of Laboratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde, ChinaBackgroundRecent studies have shown an association between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD), but the association in a population of pregnant women remains unclear.ObjectivesOur study aimed to examine the association between AIP and NAFLD in pregnant Korean women.MethodsOur study used publicly available data from Korea, which recruited singleton pregnant women between November 2014 and September 2016 who were at 10–14 weeks of gestation. The presence of NAFLD was diagnosed by liver ultrasound. AIP was calculated as log10 (TG/HDL). Participants were grouped according to AIP tertile: T1 (< 0.16, n = 195), T2 (0.16–0.32, n = 195), and T3 (>0.32, n = 196). Logistic regression models were used to estimate the relationship between AIP and NAFLD. Subgroup and sensitivity analyses were conducted to explore the stability of this relationship. Restricted cubic spline (RCS) curve fitting was employed to investigate potential non-linear associations.ResultsAfter excluding data on missing variables, 586 singleton pregnant women were finally included. The subjects included in the study had an average AIP of 0.22 (0.11, 0.37), and NAFLD occurred in 110 (18.8%) pregnant women. We observed a positive linear association between AIP and NAFLD (OR = 1.33, 95% CI: 1.19–1.48), which persisted after adjusting for potential confounders (OR = 1.2, 95% CI: 1.06–1.37). When AIP was used as a categorical variable, after adjusting for covariates, the NAFLD risk was significantly higher in the highest tertile of AIP than in the lowest group (OR = 2.02, 95% CI: 1.11–3.68). Their correlations were stable across subgroups and sensitivity analyses.ConclusionIn this secondary analysis of a prospective cohort study of pregnant Korean women, AIP was found to be positively associated with NAFLD. These outcomes might be used to screen for NAFLD in pregnant women.https://www.frontiersin.org/articles/10.3389/fnut.2025.1511952/fullsecondary analysisatherogenic index of plasmanon-alcoholic fatty liver diseaselogistic regression modelsensitivity analysis |
| spellingShingle | Rong Shuai Yuxing He Dongqian Yang Yingying Zhang Li Zhang Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study Frontiers in Nutrition secondary analysis atherogenic index of plasma non-alcoholic fatty liver disease logistic regression model sensitivity analysis |
| title | Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study |
| title_full | Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study |
| title_fullStr | Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study |
| title_full_unstemmed | Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study |
| title_short | Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study |
| title_sort | association between the atherogenic index of plasma and non alcoholic fatty liver disease in korean pregnant women secondary analysis of a prospective cohort study |
| topic | secondary analysis atherogenic index of plasma non-alcoholic fatty liver disease logistic regression model sensitivity analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1511952/full |
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