Cognitive impairment following maternal separation in rats mediated by the NAD+/SIRT3 axis via modulation of hippocampal synaptic plasticity

Cognitive impairment following maternal separation in rats mediated by the NAD+/SIRT3 axis via modulation of hippocampal synaptic plasticity

Abstract Maternal separation (MS) during early life can induce behaviors in adult animals that resemble those seen in schizophrenia, manifesting cognitive deficits. These cognitive deficits may be indicative of oxidative stress linked to mitochondrial dysfunction. However, there is limited understan...

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Main Authors: Keke Hao, Fashuai Chen, Shilin Xu, Ying Xiong, Rui Xu, Huan Huang, Chang Shu, Yisheng Lv, Gaohua Wang, Huiling Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03318-2
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